From Department of Nutrition, Exercise and Sports, Section for Preventive and Clinical Nutrition, University of Copenhagen, Frederiksberg, Denmark.
From Department of Mathematical Sciences, Data Science Lab, University of Copenhagen, Copenhagen East, Denmark.
Curr Probl Cardiol. 2023 Jan;48(1):101395. doi: 10.1016/j.cpcardiol.2022.101395. Epub 2022 Sep 10.
Alcohol consumption increases circulating high-density lipoprotein cholesterol (HDL-C), but HDL protein cargo may better reflect HDL function. This study examined the associations between alcohol intake and HDL subspecies containing or lacking apoC3, apoE, and apoJ in a well-phenotyped cohort. We performed a cross-sectional analysis of 2092 Cardiovascular Health Study participants aged 70 or older with HDL subspecies measured in stored specimens from 1998 to 1999. Associations between alcohol intake and apoA1 defined HDL subspecies lacking or containing apoC3, apoE, and apoJ, and circulating levels of total apoA1, apoC3, apoE, and apoJ were examined. HDL subspecies lacking and containing apoC3, apoE, and apoJ were all positively associated with alcohol intake, with ∼1% per additional drink per week or ∼7% per additional drink per day (subspecies without the apolipoproteins, P ≤ 2 × 10, subspecies with the apolipoproteins, P ≤ 3 × 10). Total apoA1 was also directly associated with alcohol consumption, with a 1% increase per additional drink per week (P = 1 × 10). Total apoC3 blood levels were 0.5% higher per additional drink per week (P = 0.01), but the association was driven by a few heavily drinking men. Alcohol intake was positively associated with HDL subspecies lacking and containing apoC3, apoE, or apoJ, and with total plasma apoA1. ApoC3 was directly, albeit not as robustly associated with alcohol intake. HDL protein cargo is crucial for its anti-atherosclerotic functions, but it remains to be determined whether HDL subspecies play a role in the putative association between limited alcohol intake and lower risk of coronary heart disease.
饮酒会增加循环高密度脂蛋白胆固醇（HDL-C），但 HDL 蛋白载量可能更能反映 HDL 的功能。本研究在一个经过良好表型分析的队列中，研究了饮酒与含有或缺乏载脂蛋白 C3、载脂蛋白 E 和载脂蛋白 J 的 HDL 亚类之间的关系。我们对 1998 年至 1999 年储存标本中测量的 2092 名年龄在 70 岁或以上的心血管健康研究参与者进行了横断面分析。检查了饮酒与载脂蛋白 A1 定义的缺乏或含有载脂蛋白 C3、载脂蛋白 E 和载脂蛋白 J 的 HDL 亚类以及循环总载脂蛋白 A1、载脂蛋白 C3、载脂蛋白 E 和载脂蛋白 J 水平之间的关系。缺乏和含有载脂蛋白 C3、载脂蛋白 E 和载脂蛋白 J 的 HDL 亚类均与饮酒呈正相关，每周每额外饮用一杯酒增加约 1%，每天每额外饮用一杯酒增加约 7%（无载脂蛋白亚类，P≤2×10，含载脂蛋白亚类，P≤3×10）。总载脂蛋白 A1 也与饮酒直接相关，每周每额外饮用一杯酒增加 1%（P=1×10）。每周每额外饮用一杯酒，总载脂蛋白 C3 血水平升高 0.5%（P=0.01），但这种关联是由少数酗酒男性驱动的。饮酒与缺乏和含有载脂蛋白 C3、载脂蛋白 E 或载脂蛋白 J 的 HDL 亚类以及总血浆载脂蛋白 A1 呈正相关。载脂蛋白 C3 虽然不是那么直接，但与饮酒呈正相关。HDL 蛋白载量对其抗动脉粥样硬化功能至关重要，但仍需确定 HDL 亚类是否在有限饮酒与冠心病风险降低之间的假定关联中发挥作用。
