稳定选择下的替换率。
Substitution rates under stabilizing selection.
作者信息
Hastings A
出版信息
Genetics. 1987 Jul;116(3):479-86. doi: 10.1093/genetics/116.3.479.
Abstract
Allelic substitutions under stabilizing phenotypic selection on quantitative traits are studied in Monte Carlo simulations of 8 and 16 loci. The results are compared and contrasted to analytical models based on work of M. Kimura for two and "infinite" loci. Selection strengths of S = 4Nes approximately four (which correspond to reasonable strengths of selection for quantitative characters) can retard substitution rates tenfold relative to rates under neutrality. An important finding is a strong dependence of per locus substitution rates on the number of loci.
摘要
在对8个和16个基因座的蒙特卡罗模拟中，研究了数量性状在稳定表型选择下的等位基因替换情况。将结果与基于木村资生对两个基因座和“无限”基因座研究的分析模型进行了比较和对比。选择强度S = 4Nes约为4（这对应于数量性状合理的选择强度），相对于中性条件下的替换率，可使替换率降低10倍。一个重要发现是每个基因座的替换率强烈依赖于基因座的数量。
相似文献
1
Substitution rates under stabilizing selection.稳定选择下的替换率。
Genetics. 1987 Jul;116(3):479-86. doi: 10.1093/genetics/116.3.479.
2
Molecular clock rates at loci under stabilizing selection.稳定选择下基因座的分子钟速率。
Proc Natl Acad Sci U S A. 1987 Nov;84(22):7996-8000. doi: 10.1073/pnas.84.22.7996.
3
Genetic variation maintained in multilocus models of additive quantitative traits under stabilizing selection.在稳定选择下加性数量性状的多基因座模型中维持的遗传变异。
Genetics. 1999 Jun;152(2):807-20. doi: 10.1093/genetics/152.2.807.
4
Genetic differentiation of quantitative characters between populations or species. II: Optimal selection in infinite populations.
Heredity (Edinb). 1987 Oct;59 ( Pt 2):199-212. doi: 10.1038/hdy.1987.114.
5
Dependence of expected heterozygosity on locus number with stabilizing selection and drift.在稳定选择和遗传漂变情况下，期望杂合度对基因座数量的依赖性。
J Theor Biol. 1988 Sep 9;134(1):103-12. doi: 10.1016/s0022-5193(88)80305-9.
6
A model of quantitative traits under frequency-dependent balancing selection.频率依赖平衡选择下的数量性状模型。
Proc R Soc Lond B Biol Sci. 1990 May 22;240(1297):15-28. doi: 10.1098/rspb.1990.0024.
7
Heritable genetic variation via mutation-selection balance: Lerch's zeta meets the abdominal bristle.通过突变-选择平衡产生的可遗传基因变异：勒尔奇ζ函数与腹部刚毛
Theor Popul Biol. 1984 Apr;25(2):138-93. doi: 10.1016/0040-5809(84)90017-0.
8
Mutation-selection balance and metabolic control theory.突变选择平衡与代谢控制理论
Genetics. 1991 Nov;129(3):909-23. doi: 10.1093/genetics/129.3.909.
9
A population genetics model of marker-assisted selection.一种标记辅助选择的群体遗传学模型。
Genetics. 1997 Jul;146(3):1173-83. doi: 10.1093/genetics/146.3.1173.
10
The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations.局部选择、平衡多态性和背景选择对细分种群中遗传多样性平衡模式的影响。
Genet Res. 1997 Oct;70(2):155-74. doi: 10.1017/s0016672397002954.
引用本文的文献
1
Inconsistencies in standard approximations for selection coefficients at loci affecting a polygenic character.影响多基因性状的基因座选择系数标准近似值中的不一致性。
J Math Biol. 1990;28(1):21-31. doi: 10.1007/BF00171516.
本文引用的文献
1
Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.在稳定选择下广泛中性进化的可能性，特别参考同义密码子的非随机使用
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5773-7. doi: 10.1073/pnas.78.9.5773.
2
Heritable genetic variation via mutation-selection balance: Lerch's zeta meets the abdominal bristle.通过突变-选择平衡产生的可遗传基因变异：勒尔奇ζ函数与腹部刚毛
Theor Popul Biol. 1984 Apr;25(2):138-93. doi: 10.1016/0040-5809(84)90017-0.
3
The maintenance of the genetic variability of polygenic characters by heterozygous advantage.通过杂合优势维持多基因性状的遗传变异性。
Genet Res. 1973 Aug;22(1):9-12.
4
Linkage disequilibrium and genetic variability.
Genet Res. 1974 Jun;23(3):281-9. doi: 10.1017/s0016672300014920.
5
Natural selection and the molecular clock.
Mol Biol Evol. 1986 Mar;3(2):138-55. doi: 10.1093/oxfordjournals.molbev.a040382.
6
The maintenance of genetic variability by mutation in a polygenic character with linked loci.通过具有连锁基因座的多基因性状中的突变来维持遗传变异性。
Genet Res. 1975 Dec;26(3):221-35. doi: 10.1017/s0016672300016037.
7
The effect of selection on genetic variability: a simulation study.
Genet Res. 1976 Oct;28(2):101-17. doi: 10.1017/s0016672300016797.
8
Effect of overall phenotypic selection on genetic change at individual loci.整体表型选择对单个基因座遗传变化的影响。
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6168-71. doi: 10.1073/pnas.75.12.6168.
Zotero 插件