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多糖电纺纳米纤维在创伤愈合中的应用。

Polysaccharide Electrospun Nanofibers for Wound Healing Applications.

机构信息

School of Pharmacy, Hainan University, Haikou, 570228, People's Republic of China.

School of Pharmacy, Shenyang Medical College, Shenyang, 110034, People's Republic of China.

出版信息

Int J Nanomedicine. 2022 Sep 6;17:3913-3931. doi: 10.2147/IJN.S371900. eCollection 2022.

DOI:10.2147/IJN.S371900
PMID:36097445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9464040/
Abstract

As a type of biological macromolecule, natural polysaccharides have been widely used in wound healing due to their low toxicity, good biocompatibility, degradability and reproducibility. Electrospinning is a versatile and simple technique for producing continuous nanoscale fibers from a variety of natural and synthetic polymers. The application of electrospun nanofibers as wound dressings has made great progress and they are considered one of the most effective wound dressings. This paper reviews the preparation of polysaccharide nanofibers by electrospinning and their application prospects in the field of wound healing. A variety of polysaccharide nanofibers, including chitosan, starch, alginate, and hyaluronic acid are introduced. The preparation strategy of polysaccharide electrospun nanofibers and their functions in promoting wound healing are summarized. In addition, the future prospects and challenges for the preparation of polysaccharide nanofibers by electrospinning are also discussed.

摘要

作为一种生物大分子，天然多糖由于其低毒性、良好的生物相容性、可降解性和可再生性而被广泛应用于伤口愈合领域。电纺丝是一种通用且简单的技术，可从各种天然和合成聚合物中生产连续的纳米级纤维。作为伤口敷料的电纺纳米纤维的应用取得了很大进展，被认为是最有效的伤口敷料之一。本文综述了电纺丝制备多糖纳米纤维及其在伤口愈合领域的应用前景。介绍了包括壳聚糖、淀粉、海藻酸盐和透明质酸在内的多种多糖纳米纤维。总结了多糖电纺纳米纤维的制备策略及其在促进伤口愈合方面的作用。此外，还讨论了电纺丝制备多糖纳米纤维的未来前景和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/11cbd4bdd0a7/IJN-17-3913-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/c20c6e7f5adc/IJN-17-3913-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/d016436c0979/IJN-17-3913-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/5c649f24217c/IJN-17-3913-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/a46552592659/IJN-17-3913-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/521144a523da/IJN-17-3913-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/6980fb31eb4c/IJN-17-3913-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/11cbd4bdd0a7/IJN-17-3913-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/c20c6e7f5adc/IJN-17-3913-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/d016436c0979/IJN-17-3913-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/5c649f24217c/IJN-17-3913-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/a46552592659/IJN-17-3913-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/521144a523da/IJN-17-3913-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/6980fb31eb4c/IJN-17-3913-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/9464040/11cbd4bdd0a7/IJN-17-3913-g0007.jpg

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引用本文的文献

[1]
Polysaccharide-Based Nanocarriers for Natural Antimicrobials: A Review.

Polymers (Basel). 2025-6-24

[2]
Advanced Nanomedicines for Treating Refractory Inflammation-Related Diseases.

Nanomicro Lett. 2025-7-7

[3]
Isoamylase debranching modified starch and full starch micro/nano fibers prepared by electrospinning.

RSC Adv. 2025-5-13

[4]
Electrospinning strategies targeting fibroblast for wound healing of diabetic foot ulcers.

APL Bioeng. 2025-2-25

[5]
Fabrication and Characterization of Buforin I-Loaded Electrospun Chitosan/Polyethylene Oxide Nanofibrous Membranes with Antimicrobial Activity for Food Packing Applications.

Polymers (Basel). 2025-2-19

[6]
Amylum forms typical self-assembled amyloid fibrils.

Sci Adv. 2024-8-30

[7]
Polysaccharide hydrogels for skin wound healing.

Heliyon. 2024-7-22

[8]
Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review.

Biomolecules. 2024-7-3

[9]
Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters.

Int J Pharm X. 2024-6-26

[10]
Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis.

Molecules. 2024-4-29

本文引用的文献

[1]
Nicaraven-loaded electrospun wound dressings promote diabetic wound healing via proangiogenic and immunomodulatory functions: a preclinical investigation.

Drug Deliv Transl Res. 2023-1

[2]
Electrospinning of antibacterial and anti-inflammatory Ag@hesperidin core-shell nanoparticles into nanofibers used for promoting infected wound healing.

Regen Biomater. 2022-2-18

[3]
Secretory Fluid-Aggregated Janus Electrospun Short Fiber Scaffold for Wound Healing.

Small. 2022-9

[4]
A Multifunctional Janus Electrospun Nanofiber Dressing with Biofluid Draining, Monitoring, and Antibacterial Properties for Wound Healing.

ACS Appl Mater Interfaces. 2022-3-23

[5]
Optimizing the chitosan-PCL based membranes with random/aligned fiber structure for controlled ciprofloxacin delivery and wound healing.

Int J Biol Macromol. 2022-4-30

[6]
In Situ Electrospinning of Aggregation-Induced Emission Nanofibrous Dressing for Wound Healing.

Small Methods. 2022-5

[7]
Multifunctional Biomimetic Nanofibrous Scaffold Loaded with Asiaticoside for Rapid Diabetic Wound Healing.

Pharmaceutics. 2022-1-24

[8]
Electrospun ZnO-loaded chitosan/PCL bilayer membranes with spatially designed structure for accelerated wound healing.

Carbohydr Polym. 2022-4-15

[9]
Asymmetric Wettable Composite Wound Dressing Prepared by Electrospinning with Bioinspired Micropatterning Enhances Diabetic Wound Healing.

ACS Appl Bio Mater. 2020-8-17

[10]
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice.

Drug Deliv. 2022-12

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