Zhao Wen, Liu Wenlong, Li Jiaojiao, Lin Xiao, Wang Ying
Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, People's Republic of China.
J Biomed Mater Res A. 2015 Feb;103(2):807-18. doi: 10.1002/jbm.a.35187. Epub 2014 Apr 28.
Animal polysaccharides belong to a class of biological macromolecules. They are natural biopolymers with numerous advantages for biomedical applications, such as biocompatibility, biodegradability, non-antigenicity and non-toxicity. Electrospinning is a versatile and facile technique which can produce continuous fibers with nanoscale from a wide range of natural and synthetic polymers. The review aims to provide an up-to-date overview of the preparation of animal polysaccharides nanofibers by electrospinning and their potential biomedical applications such as tissue engineering, wound healing, and drug delivery. Various animal polysaccharides including chitin and chitosan (CS), hyaluronic acid (HA), heparin and heparan sulfate (HS), and chondroitin sulfate (ChS), are discussed. The challenges and some useful strategies in electrospinning of animal polysaccharides also are summarized. In addition, future study of animal polysaccharides nanofibers by electrospinning is proposed.
动物多糖属于一类生物大分子。它们是天然生物聚合物，在生物医学应用方面具有诸多优势，如生物相容性、生物可降解性、无抗原性和无毒性。静电纺丝是一种多功能且简便的技术，可从多种天然和合成聚合物中制备出纳米级的连续纤维。这篇综述旨在提供关于通过静电纺丝制备动物多糖纳米纤维及其潜在生物医学应用（如组织工程、伤口愈合和药物递送）的最新概述。文中讨论了各种动物多糖，包括几丁质和壳聚糖（CS）、透明质酸（HA）、肝素和硫酸乙酰肝素（HS）以及硫酸软骨素（ChS）。还总结了动物多糖静电纺丝过程中的挑战和一些有用策略。此外，还提出了关于动物多糖纳米纤维静电纺丝的未来研究方向。
