Department of Internal Diseases and Diabetology, Medical University of Lodz, Lodz, Poland.
Angionica Ltd., Lodz, Poland.
Vasc Health Risk Manag. 2021 Apr 19;17:145-152. doi: 10.2147/VHRM.S307366. eCollection 2021.
Diabetic foot ulceration is a chronic complication characterized by impaired wound healing. There is a great demand for a diagnostic tool that is able to monitor and predict wound healing.
Oscillations in the microcirculation, known as flowmotion, can be monitored very distinctly and precisely using the Flow Mediated Skin Fluorescence (FMSF) technique. The flowmotion response to hypoxia was measured quantitatively in 42 patients with diabetic foot ulcers.
The flowmotion response to hypoxia parameters FM(R) and HS were used to differentiate the diabetic foot ulcers and correlate them with clinical status. In some cases, FMSF measurements were continued over the period of a year in order to monitor disease progress. The clinical status of the quarter of patients with the highest HS values (group A, HS = 50.2±18.3) was compared to the quarter with the lowest HS values (group B, HS = 4.3±1.7). The patients in the group B were identified as having low prognosis for healing and were characterized by higher incidences of hypertension, hyperlipidemia, prevalent CVD, neuropathy and nephropathy.
Impaired flowmotion responses to hypoxia induced by transient ischemia can be used for differentiation of diabetic foot ulcers and identification of cases with low prognosis for healing.
糖尿病足溃疡是一种慢性并发症，其特征是伤口愈合受损。因此，人们非常需要一种能够监测和预测伤口愈合的诊断工具。
使用血流介导的皮肤荧光（FMSF）技术，可以非常明显且精确地监测到微循环的波动，即血流运动。本研究定量测量了 42 例糖尿病足溃疡患者的低氧诱导血流运动反应。
低氧诱导血流运动反应参数 FM（R）和 HS 用于区分糖尿病足溃疡，并与临床状态相关。在某些情况下，为了监测疾病进展，FMSF 测量持续了一年。将 HS 值最高的四分之一患者（A 组，HS=50.2±18.3）的临床状态与 HS 值最低的四分之一患者（B 组，HS=4.3±1.7）进行比较。B 组的患者被认为愈合预后不佳，其特点是高血压、高血脂、心血管疾病、神经病变和肾病的发生率较高。
短暂性缺血诱导的低氧诱导血流运动反应受损可用于区分糖尿病足溃疡，并识别愈合预后不佳的病例。
