甲基苯丙胺滥用对视诱发电位的长期影响。
Long-term effects of methamphetamine abuse on visual evoked potentials.
作者信息
Mahjoob Monireh, Heydarian Samira
机构信息
Department of Optometry, Rehabilitation Faculty, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Rehabilitation Sciences, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Ophthalmic Physiol Opt. 2022 Nov;42(6):1187-1192. doi: 10.1111/opo.13048. Epub 2022 Sep 12.
PURPOSE
To compare visual evoked potential (VEP) components in normal individuals and those with long-term methamphetamine and crystal methamphetamine use.
METHODS
In this study, monocular pattern-reversal VEPs were recorded in 40 methamphetamine and crystal methamphetamine users and 38 normal individuals. Visual stimuli were high-contrast (99%) checkerboard patterns at 15 and 60 min of arc with a reversal rate of 1.53 reversals per second.
RESULTS
A significant difference was seen between the two groups for the P100 peak time for the 60 min of arc checks (p = 0.002, d = 0.75, 4.61% higher peak time in the addicted group) and the 15 min of arc checks (p = 0.004, d = 0.73, 4.78% higher peak time in the addicted group). However, other VEP components were not significantly different between the two groups.
CONCLUSIONS
The higher P100 peak time at both 15 and 60 min of arc in methamphetamine-dependent users reveals that VEPs are highly sensitive for the diagnosis of retinal and visual pathway lesions.
目的
比较正常个体与长期使用甲基苯丙胺和冰毒者的视觉诱发电位（VEP）成分。
方法
在本研究中，对40名甲基苯丙胺和冰毒使用者及38名正常个体记录单眼图形翻转VEP。视觉刺激为高对比度（99%）的棋盘格图案，视角为15和60分视角，翻转频率为每秒1.53次。
结果
两组在60分视角检查的P100峰时（p = 0.002，d = 0.75，成瘾组峰时高4.61%）和15分视角检查的P100峰时（p = 0.004，d = 0.73，成瘾组峰时高4.78%）存在显著差异。然而，两组的其他VEP成分无显著差异。
结论
甲基苯丙胺依赖者在15和60分视角时较高的P100峰时表明，VEP对视网膜和视觉通路病变的诊断高度敏感。
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