Mahjoob Monireh, Heravian Shandiz Javad, Mirzajani Ali, Ehsaei Asieh, Jafarzadehpur Ebrahim
Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran; Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Optom. 2019 Jul-Sep;12(3):192-197. doi: 10.1016/j.optom.2018.12.001. Epub 2019 Apr 23.
Visual evoked potentials (VEPs) provide important diagnostic information related to the functional integrity of the visual pathways. The aim of this study was to establish normative values of different components of pattern reversal VEPs on Iranian normal adult subjects.
Monocular and binocular pattern reversal VEPs were recorded on 59 healthy participants (22.55±3.79 years old) using the Roland RETI system for two check sizes of 15 and 60min of arc. The measured VEP components were the latencies of N75, P100, N135 and amplitude of N75-P100.
Repeated measures ANOVA showed that viewing eye condition has a significant impact on the amplitude of N75-P100 (P<0.001, F=13.89). Also, the effect of check size on the latencies of N75, P100, N135, amplitude of N75-P100 (P≤0.010), as well as the intraocular difference of P100 latency and amplitude N75-P100 (P=0.007) was significant. More specifically, the amplitude of N75-P100 in both check sizes significantly differed between gender groups (P<0.023).
According to the results of this study, VEPs components are affected by the stimulus size, monocular and binocular recording conditions and gender. Therefore, it is necessary to determine the normative values of VEPs in each population, so that the results could be used in clinical studies.
视觉诱发电位（VEP）提供了与视觉通路功能完整性相关的重要诊断信息。本研究的目的是建立伊朗正常成年受试者模式翻转VEP不同成分的正常值。
使用罗兰RETI系统，对59名健康参与者（22.55±3.79岁）进行单眼和双眼模式翻转VEP记录，刺激视标大小为15和60分视角。测量的VEP成分包括N75、P100、N135的潜伏期以及N75 - P100的波幅。
重复测量方差分析显示，观察眼状况对N75 - P100波幅有显著影响（P<0.001，F = 13.89）。此外，视标大小对N75、P100、N135潜伏期、N75 - P100波幅（P≤0.010）以及P100潜伏期和N75 - P100波幅的眼内差异（P = 0.007）均有显著影响。更具体地说，在两种视标大小下N75 - P100波幅在性别组间均有显著差异（P<0.023）。
根据本研究结果，VEP成分受刺激大小、单眼和双眼记录条件以及性别的影响。因此，有必要确定各人群VEP的正常值，以便将结果应用于临床研究。
