School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON, Canada.
ALTEX. 2022;39(4):667-693. doi: 10.14573/altex.2004041. Epub 2022 Sep 1.
Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from mul-tiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key consider-ations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.
评估环境和其他因素相关的潜在人类健康风险需要仔细评估所有相关和可用的证据，包括数据丰富和数据匮乏的因素。随着毒理学风险评估中新方法的出现，需要关于整合多个证据来源的证据的指南，以确保在定性和定量风险评估中充分考虑所有可用数据。本报告总结了来自北美和欧洲的学术界、政府和私营部门参与者在一次国际研讨会上的讨论，该研讨会旨在探索制定一个基于证据的风险评估框架，以适当的方式考虑所有可用的证据，以便对潜在的人类健康风险和相关不确定性进行最佳描述。尽管研讨会参与者之间没有达成具体共识，但对于将 21 世纪科学纳入人类健康风险评估的基于证据的风险评估所涉及的关键考虑因素，存在普遍共识。这些考虑因素已经被纳入一个总体原型框架中，用于证据整合，将在后续会议中进行更深入的探讨。
