Curatolo P, Cusmai R, Bruni O, Pruna D, Brindesi I
Funct Neurol. 1986 Oct-Dec;1(4):555-7.
An open add-on trial with flunarizine has been carried out in 27 cases of therapy resistant infantile epilepsies: 15 partial and 12 generalized epilepsies. Etiology was an hypoxic-ischemic encephalopathy (HIE) in 13 cases, cerebral malformations in 10 cases and 4 various prenatal and perinatal cases. After a 2 months baseline period, flunarizine was given in addition to the previous therapy in a 5 mg once daily dose. A single blind versus placebo study was carried out in another series of 16 cases. Better results were found in HIE cases than in malformative cases, and in cases with perinatal HIE than in cases with prenatal hypoxic encephalopathy. The improvement in symptomatic generalized epilepsies was more evident than in symptomatic partial epilepsies. Drowsiness was the only side effect reported.
对27例难治性婴儿癫痫进行了一项氟桂利嗪开放附加试验：15例部分性癫痫和12例全身性癫痫。病因是缺氧缺血性脑病（HIE）13例，脑畸形10例，4例各种产前和围产期病例。在2个月的基线期后，在先前治疗的基础上加用氟桂利嗪，剂量为每日5毫克一次。在另一组16例患者中进行了单盲与安慰剂对照研究。发现HIE病例的效果优于畸形病例，围产期HIE病例优于产前缺氧性脑病病例。症状性全身性癫痫的改善比症状性部分性癫痫更明显。嗜睡是唯一报告的副作用。
