Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal;
Inov4Agro - Institute for Innovation, Capacity building and Sustainability of Agri-Food production, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
In Vivo. 2022 Sep-Oct;36(5):2173-2185. doi: 10.21873/invivo.12943.
BACKGROUND/AIM: Obesity currently affects the whole world, with greater incidence in high-income countries, with vast economic and social costs. Broccoli harvest generates many by-products equally rich in bioactive compounds with potential anti-obesity effects. This study aimed to evaluate the anti-obesity effects of broccoli by-products flour (BF) in obese mice.
A commercial high-fat diet formulation (representing a Western diet) was used to induce obesity in mice. BF (0.67% or 1.34% weight/weight) was incorporated as a chemoprevention compound into a control and a hypercholesterolemic diet, at two different concentrations, and fed for 14 weeks to C57BL/6J mice. For a therapeutic approach, two groups were fed with the hypercholesterolemic diet for 10 weeks, and then fed with BF-supplemented diets in the last 4 weeks of the study.
BF supplementation helped to maintain a lower body weight, reduced adipose tissue accumulation, and enhanced the basal activity of superoxide dismutase and glutathione S-transferase. Although BF supplementation tended to reduce the relative liver weight increased by the Western diet, the differences were not significant.
BF appears to have a beneficial effect in preventing weight gain and fat accumulation induced by hypercholesterolemic diets.
背景/目的：肥胖目前影响着全世界，高收入国家的发病率更高，造成了巨大的经济和社会成本。西兰花收获时会产生许多同样富含具有潜在抗肥胖作用的生物活性化合物的副产物。本研究旨在评估西兰花副产物粉（BF）对肥胖小鼠的抗肥胖作用。
使用商业高脂肪饮食配方（代表西方饮食）诱导小鼠肥胖。BF（0.67%或 1.34%重量/重量）作为化学预防化合物掺入对照和高胆固醇饮食中，以两种不同浓度喂养 C57BL/6J 小鼠 14 周。对于治疗方法，两组用高胆固醇饮食喂养 10 周，然后在研究的最后 4 周用 BF 补充饮食喂养。
BF 补充有助于维持较低的体重，减少脂肪组织积累，并增强超氧化物歧化酶和谷胱甘肽 S-转移酶的基础活性。尽管 BF 补充似乎有降低由高胆固醇饮食引起的相对肝重增加的趋势，但差异不显著。
BF 似乎对预防高胆固醇饮食引起的体重增加和脂肪积累有有益作用。
