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胃癌侵犯胰腺:胰切除术作用的综述。

Gastric Cancer Invading the Pancreas: A Review of the Role of Pancreatectomy.

机构信息

Department of Surgery, University Hospital of Larissa, Larissa, Greece.

Department of Surgery, University Hospital of Larissa, Larissa, Greece

出版信息

In Vivo. 2022 Sep-Oct;36(5):2014-2019. doi: 10.21873/invivo.12927.

DOI:10.21873/invivo.12927
PMID:36099086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9463910/
Abstract

Gastric cancer is quite a common type of cancer, with significant associated mortality. Traditionally, combined resections of affected organs have been advocated in cases of locally advanced gastric cancer, in order to achieve an R0 resection. The purpose of the present study was to evaluate the role of pancreatectomy in the treatment of gastric cancer invading the pancreas by reviewing the relevant literature. The oncological benefits to survival rates of multivisceral resection are not always obvious from the relevant survival charts, especially when the pancreas is the organ invaded by the gastric cancer and gastrectomy needs to be combined with a pancreatectomy, an operation with high morbidity rates. In conclusion, careful patient selection is essential to achieving optimal results, balancing the oncological benefits in these properly selected patients against the associated morbidity of extensive resection.

摘要

胃癌是一种常见的癌症,死亡率相当高。传统上,对于局部进展期胃癌,提倡联合切除受累器官,以实现 R0 切除。本研究旨在通过复习相关文献,评估胰腺切除术在治疗侵犯胰腺的胃癌中的作用。从相关的生存图表中,多脏器切除术对生存率的肿瘤学获益并不总是明显的,尤其是当胰腺是被胃癌侵犯的器官,并且需要胃切除术联合胰腺切除术时,这种手术的发病率很高。总之,仔细选择患者对于获得最佳结果至关重要,需要权衡这些选择合适的患者的肿瘤学获益与广泛切除的相关发病率。

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PRODIGY: A Phase III Study of Neoadjuvant Docetaxel, Oxaliplatin, and S-1 Plus Surgery and Adjuvant S-1 Versus Surgery and Adjuvant S-1 for Resectable Advanced Gastric Cancer.PRODIGY 研究:新辅助多西他赛、奥沙利铂和 S-1 联合手术与手术联合辅助 S-1 治疗可切除的晚期胃癌的 III 期研究。
J Clin Oncol. 2021 Sep 10;39(26):2903-2913. doi: 10.1200/JCO.20.02914. Epub 2021 Jun 16.
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Impact of Pancreatic Resection on Survival in Locally Advanced Resectable Gastric Cancer.胰腺切除术对局部进展期可切除胃癌患者生存的影响
Cancers (Basel). 2021 Mar 14;13(6):1289. doi: 10.3390/cancers13061289.
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Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial.氟尿嘧啶+亚叶酸、奥沙利铂和多西紫杉醇与氟尿嘧啶或卡培他滨+顺铂和表柔比星用于局部晚期可切除胃或胃食管交界处腺癌的围手术期化疗(FLOT4):一项随机、2/3 期试验。
Lancet. 2019 May 11;393(10184):1948-1957. doi: 10.1016/S0140-6736(18)32557-1. Epub 2019 Apr 11.
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Nationwide Outcome of Gastrectomy with En-Bloc Partial Pancreatectomy for Gastric Cancer.胃癌根治性胃切除术联合整块胰体尾切除术的全国性结局。
J Gastrointest Surg. 2019 Dec;23(12):2327-2337. doi: 10.1007/s11605-019-04133-z. Epub 2019 Feb 28.
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Pancreaticoduodenectomy for locally advanced gastric cancer: Results from a pooled analysis.局部进展期胃癌行胰十二指肠切除术:汇总分析结果。
Asian J Surg. 2019 Mar;42(3):477-481. doi: 10.1016/j.asjsur.2018.09.005. Epub 2018 Oct 10.
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018:GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
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Chin Clin Oncol. 2018 Feb;7(1):11. doi: 10.21037/cco.2018.01.07.
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