• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

异质的跑和颠簸运动解释了造血多能祖细胞中短暂的非高斯超扩散。

Heterogeneous run-and-tumble motion accounts for transient non-Gaussian super-diffusion in haematopoietic multi-potent progenitor cells.

机构信息

Department of Bioengineering, Imperial College London, South Kensington Campus, London, United Kingdom.

Department of Life Sciences, Imperial College London, South Kensington Campus, London, United Kingdom.

出版信息

PLoS One. 2022 Sep 13;17(9):e0272587. doi: 10.1371/journal.pone.0272587. eCollection 2022.

DOI:10.1371/journal.pone.0272587
PMID:36099240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9469981/
Abstract

Multi-potent progenitor (MPP) cells act as a key intermediary step between haematopoietic stem cells and the entirety of the mature blood cell system. Their eventual fate determination is thought to be achieved through migration in and out of spatially distinct niches. Here we first analyze statistically MPP cell trajectory data obtained from a series of long time-course 3D in vivo imaging experiments on irradiated mouse calvaria, and report that MPPs display transient super-diffusion with apparent non-Gaussian displacement distributions. Second, we explain these experimental findings using a run-and-tumble model of cell motion which incorporates the observed dynamical heterogeneity of the MPPs. Third, we use our model to extrapolate the dynamics to time-periods currently inaccessible experimentally, which enables us to quantitatively estimate the time and length scales at which super-diffusion transitions to Fickian diffusion. Our work sheds light on the potential importance of motility in early haematopoietic progenitor function.

摘要

多能祖细胞 (MPP) 作为造血干细胞和整个成熟血细胞系统之间的关键中间步骤。人们认为它们的最终命运决定是通过在空间上不同的小生境中进出迁移来实现的。在这里，我们首先对从一系列对辐照小鼠颅骨的长时程 3D 体内成像实验中获得的 MPP 细胞轨迹数据进行统计分析，并报告 MPP 显示出短暂的超扩散，具有明显的非高斯位移分布。其次，我们使用一种包含 MPP 观察到的动态异质性的细胞运动的跑和停留模型来解释这些实验发现。第三，我们使用我们的模型将动力学外推到目前实验无法达到的时间段，这使我们能够定量估计超扩散向菲克扩散过渡的时间和长度尺度。我们的工作揭示了运动在早期造血祖细胞功能中的潜在重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/2849c53e0877/pone.0272587.g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/e425c5a77e80/pone.0272587.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/fbe70603a18f/pone.0272587.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/2ef3fdb7d754/pone.0272587.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/02fabc18cc50/pone.0272587.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/c78956e67de1/pone.0272587.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/19077e91ad1b/pone.0272587.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/98505d5d5493/pone.0272587.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/cd0af164bab2/pone.0272587.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/2812a1bdd51f/pone.0272587.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/fb31f7e80e27/pone.0272587.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/255d19fc1235/pone.0272587.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/df7b996aaf49/pone.0272587.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/bb3754c881a7/pone.0272587.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/48c65be2c823/pone.0272587.g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/c1557a008dad/pone.0272587.g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/2849c53e0877/pone.0272587.g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/e425c5a77e80/pone.0272587.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/fbe70603a18f/pone.0272587.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/2ef3fdb7d754/pone.0272587.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/02fabc18cc50/pone.0272587.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/c78956e67de1/pone.0272587.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/19077e91ad1b/pone.0272587.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/98505d5d5493/pone.0272587.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/cd0af164bab2/pone.0272587.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/2812a1bdd51f/pone.0272587.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/fb31f7e80e27/pone.0272587.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/255d19fc1235/pone.0272587.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/df7b996aaf49/pone.0272587.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/bb3754c881a7/pone.0272587.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/48c65be2c823/pone.0272587.g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/c1557a008dad/pone.0272587.g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/9469981/2849c53e0877/pone.0272587.g016.jpg

相似文献

1
Heterogeneous run-and-tumble motion accounts for transient non-Gaussian super-diffusion in haematopoietic multi-potent progenitor cells.异质的跑和颠簸运动解释了造血多能祖细胞中短暂的非高斯超扩散。
PLoS One. 2022 Sep 13;17(9):e0272587. doi: 10.1371/journal.pone.0272587. eCollection 2022.
2
NUP98-HOXA10hd fusion protein sustains multi-lineage haematopoiesis of lineage-committed progenitors in transplant setting.NUP98-HOXA10hd 融合蛋白在移植环境中维持谱系定向祖细胞的多谱系造血。
Cell Prolif. 2020 Sep;53(9):e12885. doi: 10.1111/cpr.12885. Epub 2020 Jul 29.
3
Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo.造血干细胞中Hoxa5的强制表达会导致体内异常红细胞生成。
Cell Cycle. 2015;14(4):612-20. doi: 10.4161/15384101.2014.992191.
4
Human mesenchymal and murine stromal cells support human lympho-myeloid progenitor expansion but not maintenance of multipotent haematopoietic stem and progenitor cells.人间充质细胞和小鼠基质细胞支持人类淋巴细胞-髓细胞祖细胞的扩增，但不支持多能造血干细胞和祖细胞的维持。
Cell Cycle. 2016;15(4):540-5. doi: 10.1080/15384101.2015.1128591.
5
Live-animal imaging of native haematopoietic stem and progenitor cells.活体内示踪造血干/祖细胞。
Nature. 2020 Feb;578(7794):278-283. doi: 10.1038/s41586-020-1971-z. Epub 2020 Feb 5.
6
The complex landscape of haematopoietic lineage commitments is encoded in the coarse-grained endogenous network.造血谱系定向分化的复杂格局编码于粗粒度的内源性网络中。
R Soc Open Sci. 2021 Nov 3;8(11):211289. doi: 10.1098/rsos.211289. eCollection 2021 Nov.
7
Hair follicle dermal cells repopulate the mouse haematopoietic system.毛囊真皮细胞可使小鼠造血系统重新填充。
J Cell Sci. 2002 Oct 15;115(Pt 20):3967-74. doi: 10.1242/jcs.00060.
8
Fickian Yet Non-Gaussian Nanoscopic Lipid Diffusion in the Raft-Mimetic Membrane.筏模型膜中菲克型而非高斯型的纳米尺度脂质扩散。
J Phys Chem B. 2023 Jun 8;127(22):4939-4951. doi: 10.1021/acs.jpcb.3c00019. Epub 2023 May 25.
9
Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.Foxc1 是造血干细胞/祖细胞龛形成的关键调节因子。
Nature. 2014 Apr 24;508(7497):536-40. doi: 10.1038/nature13071. Epub 2014 Mar 2.
10
Run-and-tumble bacteria slowly approaching the diffusive regime.进行趋避运动的细菌正缓慢趋近扩散状态。
Phys Rev E. 2020 Jun;101(6-1):062607. doi: 10.1103/PhysRevE.101.062607.

引用本文的文献

1
Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces.肠致病性大肠杆菌通过降低牵引力诱导溶组织内阿米巴在纤连蛋白上的超扩散运动。
PLoS Pathog. 2025 May 23;21(5):e1012618. doi: 10.1371/journal.ppat.1012618. eCollection 2025 May.
2
Anomalous dynamics of a passive droplet in active turbulence.主动湍流中被动液滴的反常动力学。
Nat Commun. 2024 May 2;15(1):3704. doi: 10.1038/s41467-024-47727-1.
3
Random walk and cell morphology dynamics in .随机游走与细胞形态动力学于……中 （原文不完整，翻译只能到此）

本文引用的文献

1
Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche.活体成像揭示骨髓龛中成年造血干细胞的能动性。
Cell Stem Cell. 2020 Aug 6;27(2):336-345.e4. doi: 10.1016/j.stem.2020.06.003. Epub 2020 Jun 25.
2
Live-animal imaging of native haematopoietic stem and progenitor cells.活体内示踪造血干/祖细胞。
Nature. 2020 Feb;578(7794):278-283. doi: 10.1038/s41586-020-1971-z. Epub 2020 Feb 5.
3
SciPy 1.0: fundamental algorithms for scientific computing in Python.SciPy 1.0：Python 中的科学计算基础算法。
Front Cell Dev Biol. 2023 Nov 1;11:1274127. doi: 10.3389/fcell.2023.1274127. eCollection 2023.
Nat Methods. 2020 Mar;17(3):261-272. doi: 10.1038/s41592-019-0686-2. Epub 2020 Feb 3.
4
Stochastic and Heterogeneous Cancer Cell Migration: Experiment and Theory.随机与异质肿瘤细胞迁移：实验与理论
Sci Rep. 2019 Nov 8;9(1):16297. doi: 10.1038/s41598-019-52480-3.
5
Identifying the mechanism for superdiffusivity in mouse fibroblast motility.鉴定小鼠成纤维细胞运动中超扩散的机制。
PLoS Comput Biol. 2019 Feb 14;15(2):e1006732. doi: 10.1371/journal.pcbi.1006732. eCollection 2019 Feb.
6
Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo.微制造系统中揭示的转移性癌细胞的 Lévy 样运动模式及其在体内的作用。
Nat Commun. 2018 Oct 31;9(1):4539. doi: 10.1038/s41467-018-06563-w.
7
Non-Gaussianity, population heterogeneity, and transient superdiffusion in the spreading dynamics of amoeboid cells.非高斯性、群体异质性和阿米巴样细胞扩散动力学中的瞬态超级扩散。
Phys Chem Chem Phys. 2018 Sep 12;20(35):23034-23054. doi: 10.1039/c8cp04254c.
8
From haematopoietic stem cells to complex differentiation landscapes.从造血干细胞到复杂的分化景观。
Nature. 2018 Jan 24;553(7689):418-426. doi: 10.1038/nature25022.
9
Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection.单细胞表型分析揭示感染后造血干细胞的异质性。
Stem Cells. 2017 Nov;35(11):2292-2304. doi: 10.1002/stem.2692. Epub 2017 Sep 24.
10
Chaotic Model for Lévy Walks in Swarming Bacteria.群体细菌中 Lévy 游走的混沌模型。
Phys Rev Lett. 2017 Jun 2;118(22):228102. doi: 10.1103/PhysRevLett.118.228102.