Huang Ying, Liu Wangxin, Luo Xianliang, Zhao Minjie, Wang Jing, Ullah Sami, Wei Wei, Feng Fengqin
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
College of Food Science and Engineering, Tarim University, Alar, Xinjiang, 843300, China.
NPJ Sci Food. 2024 Dec 30;8(1):115. doi: 10.1038/s41538-024-00349-9.
Medium- and long-chain triacylglycerols (MLCTs) are regarded as healthy premium oils; however, the health benefits of novel MLCTs enriched with lauric and α-linolenic acids are still not fully understood. This study examined the health benefits of lauric-α-linolenic structural lipids (ALSL) and physical mixture (PM) with a similar fatty acid composition in mice with obesity induced by the high-fat diet (HFD). The data indicated that ALSL is more effective than PM in counteracting obesity, insulin resistance, hyperlipidaemia, liver injury, and systemic inflammation in HFD-induced mice. These effects may be associated with the regulation of gut microbiota. ALSL significantly upregulated the abundance of Dubosiella, Lactobacillus, and Bifidobacterium while reducing the abundance of Ileibacterium. Furthermore, ALSL therapy increased the levels of acetic acid, propionic acid, and total short-chain fatty acids. Correlation analysis found that the positive changes in these gut microbes correlated positively with the anti-inflammatory, insulin-sensitizing, and anti-obesity effects of ALSL.
中长链甘油三酯（MLCTs）被视为优质健康油脂；然而，富含月桂酸和α-亚麻酸的新型MLCTs的健康益处仍未被完全了解。本研究在高脂饮食（HFD）诱导肥胖的小鼠中，检测了具有相似脂肪酸组成的月桂酸-α-亚麻酸结构脂质（ALSL）和物理混合物（PM）的健康益处。数据表明，在对抗HFD诱导小鼠的肥胖、胰岛素抵抗、高脂血症、肝损伤和全身炎症方面，ALSL比PM更有效。这些作用可能与肠道微生物群的调节有关。ALSL显著上调了杜氏菌属、乳杆菌属和双歧杆菌属的丰度，同时降低了艾氏杆菌属的丰度。此外，ALSL疗法增加了乙酸、丙酸和总短链脂肪酸的水平。相关性分析发现，这些肠道微生物的正向变化与ALSL的抗炎、胰岛素增敏和抗肥胖作用呈正相关。
