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新冠病毒疫苗推广的决定因素及其对健康结果的影响。

Determinants of COVID-19 Vaccine Rollouts and Their Effects on Health Outcomes.

机构信息

International Monetary Fund, Washington, DC, 20431, USA.

Georgetown University, Washington, DC, 20057, USA.

出版信息

Appl Health Econ Health Policy. 2023 Jan;21(1):71-89. doi: 10.1007/s40258-022-00757-6. Epub 2022 Sep 14.

DOI:10.1007/s40258-022-00757-6
PMID:36100820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9470512/
Abstract

BACKGROUND

Vaccination against the coronavirus disease (SARS-CoV-2) is understood to be the key way out of the COVID-19 pandemic. Limited evidence exists on the determinants of vaccine rollouts and their health effects at the country level.

OBJECTIVE

Examine the determinants of COVID-19 vaccine rollouts and their effects on health outcomes.

METHODS

Ordinary least squares regressions with standard errors clustered at the country level for Cross-section and Panel daily data of vaccinations and various health outcomes (new COVID-19 cases, fatalities, intensive care unit (ICU) admissions) for an unbalanced sample of about 200 countries during the period 16 December 2020 to 20 June 2021.

RESULTS

We find evidence that: (i) early vaccine procurement, domestic production of vaccines, the severity of the pandemic, a country's health infrastructure, and vaccine acceptance are significant determinants of the speed of vaccination rollouts; (ii) vaccine deployment significantly reduces new COVID-19 infections, Intensive Care Unit (ICU) admissions, and fatalities, and is more effective when coupled with stringent containment measures, or when a country is experiencing a large outbreak; and (iii) COVID-19 cases in neighboring countries can lead to an increase in a country's domestic caseload, and hamper efforts in taming its own local outbreak.

CONCLUSIONS

By providing an early broad overview of the quantitative empirical estimates of the determinants of vaccine rollouts and the effects of COVID-19 vaccines, our paper can help policymakers make informed decisions about local and global distributions of vaccines, as well as related policy tools, such as containment measure.

摘要

背景

接种针对冠状病毒病(SARS-CoV-2)的疫苗被认为是摆脱 COVID-19 大流行的关键途径。关于疫苗推广的决定因素及其对国家层面健康结果的影响,证据有限。

目的

研究 COVID-19 疫苗推广的决定因素及其对健康结果的影响。

方法

使用横截面和面板每日数据的普通最小二乘法回归,标准误差在国家层面上聚类,对 2020 年 12 月 16 日至 2021 年 6 月 20 日期间约 200 个国家的未平衡样本进行了接种和各种健康结果(新的 COVID-19 病例、死亡、重症监护病房(ICU)入院)的分析。

结果

我们发现有证据表明:(i)早期疫苗采购、国内疫苗生产、大流行的严重程度、国家的卫生基础设施和疫苗接受度是疫苗推广速度的重要决定因素;(ii)疫苗部署显著降低了新的 COVID-19 感染、重症监护病房(ICU)入院和死亡人数,当与严格的遏制措施结合使用时,或者当一个国家正在经历大规模爆发时,疫苗的效果更为显著;(iii)邻国的 COVID-19 病例可能导致一个国家国内病例增加,并阻碍其控制当地爆发的努力。

结论

通过提供疫苗推广的决定因素和 COVID-19 疫苗效果的定量实证估计的早期广泛概述,我们的论文可以帮助政策制定者就疫苗在本地和全球的分配以及相关政策工具(如遏制措施)做出明智的决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/588920dbec3a/40258_2022_757_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/48991d448056/40258_2022_757_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/6a4c60d89a5f/40258_2022_757_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/d1e25fdd2ca7/40258_2022_757_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/acb804325ec5/40258_2022_757_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/588920dbec3a/40258_2022_757_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/48991d448056/40258_2022_757_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/6a4c60d89a5f/40258_2022_757_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/d1e25fdd2ca7/40258_2022_757_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/acb804325ec5/40258_2022_757_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/9470512/588920dbec3a/40258_2022_757_Fig5_HTML.jpg

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