Chemical Engineering Department, Babol Noshirvani University of Technology, Babol, Mazandaran, Iran.
Department of Chemical Engineering, Faculty of Engineering and Technology, University of Mazandaran, Babolsar, Iran.
Curr Pharm Biotechnol. 2023;24(9):1079-1093. doi: 10.2174/1389201023666220913153725.
Chronic wound healing is a time-consuming and complicated process. Severe risk for wound healing that can be life-threatening is bacterial invasion and wound during the healing process. Therefore, it is necessary to use a sui barrier to create a controlled environment for wound healing. Various wound dressings such as hydrocolloids, hydrogels, sponges, foams, films, and micro and nanofibers have been explored in recent decades. High surface-to-volume ratio, high similarity to the biological structure of the extracellular matrix, high porosity and very small pore size are some advantages of nanofibers that have become potential candidates for wound healing applications. Different methods are used to fabricate nanofibers like drawing-processing, template synthesis, self-assembly, phase separation, force-spinning and electrospinning. Electrospinning is the most desirable method due to the possibility of producing independent, accessible and controllable nanofibers. The fiberbased wound dressings and their manufacturing methods have been extensively discussed.
慢性伤口愈合是一个耗时且复杂的过程。严重的伤口愈合风险可能危及生命，即细菌入侵和伤口在愈合过程中。因此，有必要使用合适的屏障为伤口愈合创造一个可控的环境。在最近几十年中，已经探索了各种伤口敷料，如水胶体、水凝胶、海绵、泡沫、薄膜以及微纳纤维。高的比表面积与体积比、与细胞外基质的生物结构高度相似、高孔隙率和非常小的孔径是纳米纤维的一些优势，使其成为伤口愈合应用的潜在候选材料。不同的方法被用于制造纳米纤维，如拉伸加工、模板合成、自组装、相分离、力纺丝和静电纺丝。由于能够生产独立、可及和可控的纳米纤维，静电纺丝是最理想的方法。纤维基伤口敷料及其制造方法已被广泛讨论。
