Alesci Alessio, Capillo Gioele, Fumia Angelo, Messina Emmanuele, Albano Marco, Aragona Marialuisa, Lo Cascio Patrizia, Spanò Nunziacarla, Pergolizzi Simona, Lauriano Eugenia Rita
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Biology (Basel). 2022 Jul 12;11(7):1045. doi: 10.3390/biology11071045.
Dendritic cells (DCs) are antigen-presenting cells (APCs) that regulate the beginning of adaptive immune responses. The mechanisms of tolerance to antigens moving through the digestive tract are known to be regulated by intestinal DCs. Agnatha and Gnathostoma are descendants of a common ancestor. The Ostracoderms gave rise to Cyclostomes, whereas the Placoderms gave rise to Chondrichthyes. and are two evolutionary lines of bony fishes. and descend from the . From , and evolved. Using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II, this study aimed to characterize intestinal DCs, from myxines to teleosts. The findings reveal that DCs are positive for the antibodies tested, highlighting the presence of DCs and DC-like cells phylogenetically from myxines, for the first time, to teleosts. These findings may aid in improving the level of knowledge about the immune system's evolution and these sentinel cells, which are crucial to the body's defense.
树突状细胞（DCs）是调节适应性免疫反应起始的抗原呈递细胞（APCs）。已知肠道DCs可调节对通过消化道的抗原的耐受机制。无颌类和有颌类是共同祖先的后代。甲胄鱼纲演化出圆口纲，而盾皮鱼纲演化出软骨鱼纲。硬骨鱼有两条进化路线。 和 从 演化而来。从 演化出了 和 。本研究使用针对Toll样受体2（TLR-2）、朗格汉斯蛋白/CD207和主要组织相容性复合体II（MHC II）的免疫组织化学方法，旨在对从盲鳗到硬骨鱼的肠道DCs进行特征描述。研究结果显示，DCs对所检测的抗体呈阳性反应，首次从系统发育角度证实了从盲鳗到硬骨鱼均存在DCs和DC样细胞。这些发现可能有助于提高我们对免疫系统进化以及这些对机体防御至关重要的哨兵细胞的认识水平。
