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潜在神经保护作用的 calretinin-N18 和 calbindin-D28k 在视网膜的成年斑马鱼暴露在不同波长的光。

Potential Neuroprotective Role of Calretinin-N18 and Calbindin-D28k in the Retina of Adult Zebrafish Exposed to Different Wavelength Lights.

机构信息

Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.

出版信息

Int J Mol Sci. 2023 Jan 6;24(2):1087. doi: 10.3390/ijms24021087.

DOI:10.3390/ijms24021087
PMID:36674603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9862630/
Abstract

The incidence rates of light-induced retinopathies have increased significantly in the last decades because of continuous exposure to light from different electronic devices. Recent studies showed that exposure to blue light had been related to the pathogenesis of light-induced retinopathies. However, the pathophysiological mechanisms underlying changes induced by light exposure are not fully known yet. In the present study, the effects of exposure to light at different wavelengths with emission peaks in the blue light range (400-500 nm) on the localization of Calretinin-N18 (CaR-N18) and Calbindin-D28K (CaB-D28K) in adult zebrafish retina are studied using double immunofluorescence with confocal laser microscopy. CaB-D28K and CaR-N18 are two homologous cytosolic calcium-binding proteins (CaBPs) implicated in essential process regulation in central and peripheral nervous systems. CaB-D28K and CaR-N18 distributions are investigated to elucidate their potential role in maintaining retinal homeostasis under distinct light conditions and darkness. The results showed that light influences CaB-D28K and CaR-N18 distribution in the retina of adult zebrafish, suggesting that these CaBPs could be involved in the pathophysiology of retinal damage induced by the short-wavelength visible light spectrum.

摘要

在过去的几十年中，由于持续暴露于各种电子设备发出的光，光诱导性视网膜病变的发病率显著增加。最近的研究表明，蓝光暴露与光诱导性视网膜病变的发病机制有关。然而，光暴露引起的变化的病理生理机制尚未完全清楚。在本研究中，使用共聚焦激光显微镜的双免疫荧光技术，研究了在蓝光范围内（400-500nm）具有发射峰的不同波长的光暴露对成年斑马鱼视网膜中 Calretinin-N18（CaR-N18）和 Calbindin-D28K（CaB-D28K）定位的影响。CaB-D28K 和 CaR-N18 是两种同源细胞溶质钙结合蛋白（CaBPs），参与中枢和外周神经系统中基本过程的调节。研究 CaB-D28K 和 CaR-N18 的分布，以阐明它们在不同光照条件和黑暗下维持视网膜内稳态的潜在作用。结果表明，光会影响成年斑马鱼视网膜中 CaB-D28K 和 CaR-N18 的分布，提示这些 CaBPs 可能参与了短波长可见光光谱引起的视网膜损伤的病理生理学过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34e0/9862630/ea5e6d3dd7b5/ijms-24-01087-g005.jpg
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