Tuesta Marcelo, Yáñez-Sepúlveda Rodrigo, Verdugo-Marchese Humberto, Mateluna Cristián, Alvear-Ordenes Ildefonso
Exercise and Rehabilitation Sciences Laboratory, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile.
Laboratory of Sport Sciences, Centro de Medicina Deportiva Sports MD, Viña del Mar 2521156, Chile.
Biology (Basel). 2022 Jul 19;11(7):1073. doi: 10.3390/biology11071073.
Using muscle oxygenation to evaluate the therapeutic effects of physical exercise in pathologies through near-infrared spectroscopy (NIRS) is of great interest. The aim of this review was to highlight the use of muscle oxygenation in exercise interventions in clinical trials and to present the technological characteristics related to the equipment used in these studies. PubMed, WOS, and Scopus databases were reviewed up to December 2021. Scientific articles that evaluated muscle oxygenation after exercise interventions in the sick adult population were selected. The PEDro scale was used to analyze the risk of bias (internal validity). The results were presented grouped in tables considering the risk of bias scores, characteristics of the devices, and the effects of exercise on muscle oxygenation. All the stages were carried out using preferred reporting items for systematic reviews and meta-analyses (PRISMA). The search strategy yielded 820 clinical studies, of which 18 met the eligibility criteria. This review detailed the characteristics of 11 NIRS devices used in clinical trials that used physical exercise as an intervention. The use of this technology made it possible to observe changes in muscle oxygenation/deoxygenation parameters such as tissue saturation, oxyhemoglobin, total hemoglobin, and deoxyhemoglobin in clinical trials of patients with chronic disease. It was concluded that NIRS is a non-invasive method that can be used in clinical studies to detect the effects of physical exercise training on muscle oxygenation, hemodynamics, and metabolism. It will be necessary to unify criteria such as the measurement site, frequency, wavelength, and variables for analysis. This will make it possible to compare different models of exercise/training in terms of time, intensity, frequency, and type to obtain more precise conclusions about their benefits for patients.
利用肌肉氧合作用通过近红外光谱（NIRS）评估体育锻炼对疾病的治疗效果具有重要意义。本综述的目的是强调肌肉氧合作用在临床试验运动干预中的应用，并介绍与这些研究中使用的设备相关的技术特征。截至2021年12月，对PubMed、WOS和Scopus数据库进行了检索。选择了评估患病成年人群运动干预后肌肉氧合作用的科学文章。使用PEDro量表分析偏倚风险（内部效度）。结果以表格形式呈现，综合考虑偏倚风险评分、设备特征以及运动对肌肉氧合的影响。所有阶段均按照系统评价和Meta分析的首选报告项目（PRISMA）进行。检索策略共获得820项临床研究，其中18项符合纳入标准。本综述详细介绍了11种用于以体育锻炼为干预措施的临床试验的近红外光谱设备的特征。在慢性病患者的临床试验中，使用该技术能够观察到肌肉氧合/脱氧参数的变化，如组织饱和度、氧合血红蛋白、总血红蛋白和脱氧血红蛋白。得出的结论是，近红外光谱是一种非侵入性方法，可用于临床研究，以检测体育锻炼训练对肌肉氧合、血流动力学和代谢的影响。有必要统一测量部位、频率、波长和分析变量等标准。这将使得能够在时间、强度、频率和类型方面比较不同的运动/训练模式，从而就其对患者的益处得出更精确的结论。
