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汞暴露与 2 型糖尿病风险：系统评价和荟萃分析。

Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis.

机构信息

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman Medical University, Kerman, Iran.

Department of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

出版信息

Int J Clin Pract. 2022 Sep 2;2022:7640227. doi: 10.1155/2022/7640227. eCollection 2022.

DOI:10.1155/2022/7640227
PMID:36101810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9463027/
Abstract

METHODS

Scopus and PubMed databases were systematically searched from their inception to November 2021 to obtain pertinent studies. Standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the difference in Hg levels between people with and without T2DM. The association of the Hg exposure with T2DM was assessed using a random-effects model by pooling the odds ratios (ORs) and 95% CIs.

RESULTS

A total of 17 studies, with 42,917 participants, aged ≥18 years, were analyzed. Overall, Hg levels were significantly higher in T2DM patients compared with non-T2DM controls (SMD = 1.07; 95%CI = 0.59 to 1.55, ≤ 0.001), with significant heterogeneity across studies (I = 96.1%; =≤0.001). No significant association was found between Hg exposure and risk of T2DM in the overall analysis and subgroup analysis based on the source of sample and study design. However, higher exposure to Hg was related to reduced risk of T2DM in men (OR = 0.71; 95%CI = 0.57 to 0.88), but not in women. No significant evidence for publication bias was detected.

CONCLUSIONS

Although the Hg level in T2DM is significantly higher than that of nondiabetics, there was no association between Hg exposure and the overall risk of T2DM. Nevertheless, our study shows that higher exposure to Hg might reduce the risk of T2DM in men.

摘要

方法

系统检索 Scopus 和 PubMed 数据库，检索时间从建库至 2021 年 11 月，以获取相关研究。计算标准化均数差值（SMD）及其 95%置信区间（CI），以评估 T2DM 患者与非 T2DM 患者的汞水平差异。采用随机效应模型汇总优势比（OR）及其 95%CI 来评估汞暴露与 T2DM 的相关性。

结果

共纳入 17 项研究，总计 42917 名年龄≥18 岁的参与者。总体而言，T2DM 患者的汞水平明显高于非 T2DM 对照组（SMD=1.07；95%CI=0.59 至 1.55，P≤0.001），各研究间存在显著异质性（I=96.1%；P≤0.001）。在总体分析和基于样本来源及研究设计的亚组分析中，均未发现汞暴露与 T2DM 风险之间存在显著相关性。然而，较高的汞暴露与男性 T2DM 风险降低相关（OR=0.71；95%CI=0.57 至 0.88），但在女性中无此相关性。未发现发表偏倚的显著证据。

结论

尽管 T2DM 患者的汞水平明显高于非糖尿病患者，但汞暴露与 T2DM 的总体风险之间无相关性。然而，我们的研究表明，较高的汞暴露可能降低男性 T2DM 的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/519fa0abb6ce/IJCLP2022-7640227.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/b0d0234de297/IJCLP2022-7640227.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/2ff08043f4c7/IJCLP2022-7640227.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/519fa0abb6ce/IJCLP2022-7640227.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/b0d0234de297/IJCLP2022-7640227.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/16489c2b2a54/IJCLP2022-7640227.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/2e3347947cd9/IJCLP2022-7640227.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/432e21ddeb9a/IJCLP2022-7640227.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/2cda493667bf/IJCLP2022-7640227.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/2ff08043f4c7/IJCLP2022-7640227.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea8/9463027/519fa0abb6ce/IJCLP2022-7640227.007.jpg

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