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COVID-19 对院外心脏骤停的影响:来自德国复苏注册中心的基于登记的队列研究。

Impact of COVID-19 on out-of-hospital cardiac arrest: A registry-based cohort-study from the German Resuscitation Registry.

机构信息

Institute for Emergency Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.

Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

出版信息

PLoS One. 2022 Sep 14;17(9):e0274314. doi: 10.1371/journal.pone.0274314. eCollection 2022.

Abstract

INTRODUCTION

The global COVID-19 pandemic effects people and the health system. Some international studies reported an increasing number of out-of-hospital cardiac arrest (OHCA). Comparable studies regarding the impact of COVID-19 on incidence and outcome of OHCA are not yet available for Germany.

MATERIALS AND METHODS

This epidemiological study from the German Resuscitation Registry (GRR) compared a non-pandemic period (01.03.2018-28.02.2019) and a pandemic period (01.03.2020-28.02.2021) regarding the pandemic-related impact on OHCA care.

RESULTS

A total of 18,799 cases were included. The incidence of OHCA (non-pandemic 117.9 vs. pandemic period 128.0/100,000 inhabitants) and of OHCA with resuscitation attempted increased (66.0 vs. 69.1/100,000). OHCA occurred predominantly and more often at home (62.8% vs. 66.5%, p<0.001). The first ECG rhythm was less often shockable (22.2% vs. 20.3%, p = 0.03). Fewer cases of OHCA were observed (58.6% vs. 55.6% p = 0.02). Both the bystander resuscitation rate and the proportion of telephone guided CPR remained stable (38.6% vs. 39.8%, p = 0.23; and 22.3% vs. 22.5%, p = 0.77). EMS arrival times increased (08:39 min vs. 09:08 min, p<0.001). Fewer patients reached a return of spontaneous circulation (ROSC) (45.4% vs. 40.9%, p<0.001), were admitted to hospital (50.2% vs. 45.0%, p<0.001), and discharged alive (13.9% vs. 10.2%, p<0.001).

DISCUSSION

Survival after OHCA significantly decreased while the bystander resuscitation rate remained stable. However, longer EMS arrival times and fewer cases of witnessed OHCA may have contributed to poorer survival. Any change to EMS systems in the care of OHCA should be critically evaluated as it may mean a real loss of life-regardless of the pandemic situation.

摘要

简介

全球 COVID-19 大流行对人和医疗系统产生了影响。一些国际研究报告称,院外心脏骤停(OHCA)的数量有所增加。目前尚无针对德国 COVID-19 对 OHCA 发病率和结局影响的可比研究。

材料和方法

本研究来自德国复苏注册中心(GRR),比较了非大流行时期(2018 年 3 月 1 日至 2019 年 2 月 28 日)和大流行时期(2020 年 3 月 1 日至 2021 年 2 月 28 日)与 COVID-19 相关的 OHCA 护理方面的影响。

结果

共纳入 18799 例患者。OHCA 的发病率(非大流行时期为 117.9/100000 居民,大流行时期为 128.0/100000 居民)和尝试复苏的 OHCA 发病率(大流行时期为 66.0/100000 居民,大流行时期为 69.1/100000 居民)均有所增加。OHCA 主要发生在家中,且发生率更高(62.8%vs.66.5%,p<0.001)。首次心电图节律更不易除颤(22.2%vs.20.3%,p=0.03)。OHCA 发生率更低(58.6%vs.55.6%,p=0.02)。旁观者心肺复苏率和电话指导 CPR 的比例保持稳定(38.6%vs.39.8%,p=0.23;22.3%vs.22.5%,p=0.77)。EMS 到达时间延长(08:39 分钟 vs.09:08 分钟,p<0.001)。达到自主循环恢复(ROSC)的患者更少(45.4%vs.40.9%,p<0.001),住院患者更少(50.2%vs.45.0%,p<0.001),出院存活者更少(13.9%vs.10.2%,p<0.001)。

讨论

OHCA 后生存率显著下降,而旁观者心肺复苏率保持稳定。然而,EMS 到达时间延长和目击 OHCA 病例减少可能导致生存率下降。在 OHCA 护理中,任何对 EMS 系统的改变都应进行严格评估,因为这可能意味着真正的生命损失——无论大流行情况如何。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e55/9473624/04e2b0587da5/pone.0274314.g001.jpg

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