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BT20乳腺癌细胞系中表皮生长因子受体基因的扩增。

Amplification of the epidermal growth factor receptor gene in the BT20 breast carcinoma cell line.

作者信息

Lebeau J, Goubin G

出版信息

Int J Cancer. 1987 Aug 15;40(2):189-91. doi: 10.1002/ijc.2910400210.

DOI:10.1002/ijc.2910400210
PMID:3610387
Abstract

Southern blot-hybridization analysis of 10 breast carcinoma cell lines demonstrated an amplification of the epidermal growth factor (EGF) receptor gene in the BT20 cell line. The gene was amplified 10- to 14-fold when compared to the level seen in human placental DNA. Northern blot analysis indicated an increased level of transcription in this cell line which probably accounts for the high level of the EGF receptor reported in the BT20 cell line.

摘要

对10种乳腺癌细胞系进行的Southern印迹杂交分析表明，BT20细胞系中表皮生长因子（EGF）受体基因发生了扩增。与人类胎盘DNA中的水平相比，该基因扩增了10至14倍。Northern印迹分析表明该细胞系中转录水平增加，这可能是BT20细胞系中报道的EGF受体高水平的原因。

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