Institute of Medical and Biological Engineering (iMBE), School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK.
Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), School of Computing, University of Leeds, Leeds, LS2 9BW, UK.
Ann Biomed Eng. 2023 Jan;51(1):174-188. doi: 10.1007/s10439-022-03072-2. Epub 2022 Sep 14.
Finite element models (FEMs) of the spine commonly use a limited number of simplified geometries. Nevertheless, the geometric features of the spine are important in determining its FEM outcomes. The link between a spinal segment's shape and its biomechanical response has been studied, but the co-variances of the shape features have been omitted. We used a principal component (PCA)-based statistical shape modelling (SSM) approach to investigate the contribution of shape features to the intradiscal pressure (IDP) and the facets contact pressure (FCP) in a cohort of synthetic L4/L5 functional spinal units under axial compression. We quantified the uncertainty in the FEM results, and the contribution of individual shape modes to these results. This parameterisation approach is able to capture the variability in the correlated anatomical features in a real population and sample plausible synthetic geometries. The first shape mode ([Formula: see text]) explained 22.6% of the shape variation in the subject-specific cohort used to train the SSM, and had the largest correlation with, and contribution to IDP (17%) and FCP (11%). The largest geometric variation in ([Formula: see text]) was in the annulus-nucleus ratio.
脊柱的有限元模型（FEM）通常使用有限数量的简化几何形状。然而，脊柱的几何特征对于确定其 FEM 结果很重要。已经研究了脊柱节段形状与其生物力学响应之间的关系，但忽略了形状特征的协方差。我们使用基于主成分（PCA）的统计形状建模（SSM）方法来研究在轴向压缩下，一组合成 L4/L5 功能脊柱单元中，形状特征对椎间盘内压力（IDP）和小面接触压力（FCP）的贡献。我们量化了 FEM 结果的不确定性，以及各个形状模式对这些结果的贡献。这种参数化方法能够捕捉真实人群中相关解剖特征的可变性，并模拟合理的合成几何形状。用于训练 SSM 的特定于主题的队列中，第一形状模式 ([Formula: see text]) 解释了 22.6%的形状变化，并且与 IDP（17%）和 FCP（11%）的相关性最大，对其的贡献也最大。([Formula: see text]) 中的最大几何变化是在环-核比中。
