Rodriguez-Salvador Marisela, Ruiz-Cantu Laura
Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, N.L., Mexico.
Centre for Additive Manufacturing, The University of Nottingham, Nottingham, UK.
Int J Bioprint. 2018 Dec 26;5(1):170. doi: 10.18063/ijb.v5i1.170. eCollection 2019.
Science and technology (S&T) on three-dimensional (3D) bioprinting is growing at an increasingly accelerated pace; one major challenge represents how to develop new solutions for frequent oral diseases such as periodontal problems and loss of alveolar bone. 3D bioprinting is expected to revolutionize the health industry in the upcoming years. In dentistry, this technology can become a significant contributor. This study applies a Competitive Technology Intelligence methodology to uncover the main S&T drivers in this domain. Looking at a 6-year period from 2012 to 2018 an analysis of scientific and technology production was made. Three principal S& T drivers were identified: Scaffolds development, analysis of natural and synthetic materials, and the study of scaffold characteristics. Innovative hybrid and multiphasic scaffolds are being developed to regenerate periodontal tissue and alveolar bone by combining them with stem cells from the pulp or periodontal ligament. To improve scaffolds performance, biodegradable synthetic polymers are often used in combination with bioceramics. The characteristics of scaffolds such as fiber orientation, porosity, and geometry, were also investigated. This research contributes to people interested in bringing innovative solutions to the health industry, particularly by applying state-of-the-art technologies such as 3D bioprinting, in this case for dental tissues and dental bone diseases.
三维（3D）生物打印领域的科学技术发展速度日益加快；其中一个主要挑战是如何为诸如牙周问题和牙槽骨丧失等常见口腔疾病开发新的解决方案。预计3D生物打印将在未来几年给医疗行业带来变革。在牙科领域，这项技术有望成为重要的推动力量。本研究运用竞争技术情报方法来揭示该领域主要的科技驱动因素。通过对2012年至2018年这6年期间的科技产出进行分析，确定了三个主要的科技驱动因素：支架开发、天然和合成材料分析以及支架特性研究。目前正在开发创新的混合和多相支架，通过将其与牙髓或牙周膜干细胞相结合来再生牙周组织和牙槽骨。为了提高支架性能，可生物降解的合成聚合物常与生物陶瓷联合使用。同时，还对支架的纤维取向、孔隙率和几何形状等特性进行了研究。这项研究有助于那些有志于为医疗行业带来创新解决方案的人士，特别是通过应用3D生物打印等前沿技术，在本案例中用于治疗牙齿组织和牙骨疾病。
