Department of Healthcare, Municipality of Skellefteå, Skellefteå, Västerbotten, Sweden.
Division of Wood Science and Engineering, Department of Engineering Sciences and Mathematics, Luleå University of Technology, Skellefteå, Västerbotten, Sweden.
PLoS One. 2022 Sep 15;17(9):e0274023. doi: 10.1371/journal.pone.0274023. eCollection 2022.
The main objectives of the study were to explore whether laser Photobiomodulation (PBM) in addition to traditional dressing of hard-to-heal venous leg ulcer, reduced healing time of the ulcer and if the duration of the ulcer before PBM impacted the treatment time with PBM to healing. The intervention group was frail, elderly patients with home healthcare in the municipality of Skellefteå, registered in the Swedish quality registry RiksSar for ulcer treatment with hard-to-heal venous leg ulcer. The control group with equivalent physical conditions was obtained from the same quality registry. Definition of hard-to-heal ulcer was six weeks duration or more. The PBM was performed two times per week with laser type infrared GaAs, 904nm, 60mW, and 700Hz, targeting lymphatic area and ulcer area. Laser type red visible, GaAllnp, 635nm, 75mW and 250Hz, targeting ulcer area. The intervention group treated with PBM in addition to traditional dressing healed significantly faster than the control group with a mean of 123 days (p = 0.0001). Duration of the ulcer before PBM did not impact the healing time. To conclude, the findings indicate that using PBM in addition to dressing may have multiple benefits on hard-to-heal venous leg ulcer, saving valuable time and resources for patients, healthcare providers, and institutions.
本研究的主要目的是探索激光光生物调节(PBM)是否除了传统的难愈合静脉溃疡敷料之外,还可以缩短溃疡的愈合时间,以及 PBM 治疗前溃疡的持续时间是否会影响 PBM 治疗的时间。干预组是斯考奈省的体弱老年人,他们接受家庭保健,在瑞典质量登记处 RiksSar 登记为患有难以愈合的静脉性腿部溃疡。对照组则是来自同一质量登记处的具有同等身体状况的患者。难以愈合溃疡的定义为病程持续六周或以上。PBM 采用 904nm、60mW、700Hz 的红外 GaAs 激光,以淋巴管和溃疡区域为目标,每周进行两次治疗。采用 635nm、75mW、250Hz 的红色可见 GaAllnp 激光,以溃疡区域为目标。接受 PBM 治疗的干预组与仅接受传统敷料治疗的对照组相比,愈合速度明显更快,平均愈合时间为 123 天(p=0.0001)。PBM 治疗前溃疡的持续时间并未影响愈合时间。总之,这些发现表明,除了敷料之外,使用 PBM 可能对难以愈合的静脉性腿部溃疡具有多种益处,可以为患者、医疗保健提供者和医疗机构节省宝贵的时间和资源。