Wiessmann K J, Steinijans V W, Brossmann D
Arzneimittelforschung. 1979;29(2):329-33.
Four respiratory analeptics were examined in a CO2 rebreathing experiment with increase from 0--6% in the inspiratory CO2 concentration during 30 min on 24 healthy young men. The respiratory response curves (VE/pCO2) showed a parabolic shape. They were examined on parallel shift and change of slope. The "excitability ratio" is the first derivative of the response parabola and as such becomes a linear function of the actual arterial CO2 partial pressure. The following effects have been shown: 1. 150 mg amiphenazole (2.07 mg/kg) cause a small rise in the ventilation by accelerating the frequency at increased CO2 partial pressures above 45 mmHg. 2. 240 mg theophylline ethylenediamine (3.32 mg/kg) produce a nearly parallel upward-shift of the respiratory response curve, i.e., the respiratory minute volume increases independently by a deepening of the respiration. 3. 450 mg prethcamide (6.22 mg/kg) cause a slight increase of the "excitability ratio" at CO2 partial pressures above 45 mmHg. The CO2-dependent respiratory minute volume is not changed significantly but the pattern of breathing changes by accelerating the frequency and decreasing the tidal volume. 4. 40 mg fominobene (0.55 mg/kg) raise the "excitability ratio" convincingly at CO2 partial pressures above 40 mmHg. However, the total volume ventilated during the experiment does not increase because of a diminished ventilation at rest.
对24名健康年轻男性进行了二氧化碳再呼吸实验，在30分钟内将吸气二氧化碳浓度从0%提高到6%，对四种呼吸兴奋剂进行了检测。呼吸反应曲线（VE/pCO2）呈抛物线形状。对它们进行了平行移动和斜率变化的检测。“兴奋率”是反应抛物线的一阶导数，因此成为实际动脉二氧化碳分压的线性函数。结果表明有以下效应：1. 150毫克阿米苯唑（2.07毫克/千克）通过在二氧化碳分压高于45毫米汞柱时加快频率，使通气量略有增加。2. 240毫克氨茶碱乙二胺（3.32毫克/千克）使呼吸反应曲线几乎平行向上移动，即呼吸分钟量通过加深呼吸而独立增加。3. 450毫克普雷沙米特（6.22毫克/千克）在二氧化碳分压高于45毫米汞柱时使“兴奋率”略有增加。依赖二氧化碳的呼吸分钟量没有明显变化，但呼吸模式通过加快频率和减小潮气量而改变。4. 40毫克福米诺苯（0.55毫克/千克）在二氧化碳分压高于40毫米汞柱时显著提高“兴奋率”。然而，由于静息时通气量减少，实验期间的总通气量没有增加。
