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口腔鳞状细胞癌患者唾液和血浆中唾液α淀粉酶水平的评估

Evaluation of Salivary and Plasma Levels of Salivary α-Amylase in Patients of Oral Squamous Cell Carcinoma.

作者信息

Raaj Vaibhava, Raina Sakshi, Raj Nikhil, Sehgal Rajat

机构信息

Private Practitioner, Patna, Bihar, India.

Dental Officer, ECHS Polyclinic, Ministry of Defence, Samastipur, Bihar, India.

出版信息

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S344-S351. doi: 10.4103/jpbs.jpbs_47_22. Epub 2022 Jul 13.

DOI:10.4103/jpbs.jpbs_47_22
PMID:36110670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9469276/
Abstract

AIM

The aim of the study was to evaluate levels of salivary alpha-amylase (sAA) in plasma and saliva of patients with oral squamous cell carcinoma (SCC). The diurnal patterns of sAA and its response to stress were also determined.

MATERIALS AND METHODS

A randomized clinical study was conducted to evaluate the salivary and plasma levels of sAA in three study groups, containing ten subjects each. sAA concentration in plasma and saliva samples was measured using Bioassay Technology Laboratory human alpha-amylase kits, and the levels were compared among control and test groups.

RESULTS

In all groups, the mean plasma α-amylase level and mean saliva α-amylase level show an increasing trend with time, i.e., from morning to night, and among the groups, it was highest in Group III followed by Group II and Group I the least (Group III, Group II, and Group I) at all times with significantly higher mean values in Group III subjects at all times of a day.

CONCLUSION

Alpha-amylase is one of the principal salivary proteins and its secretion is regulated by the sympathetic nervous system. The measurement of salivary alpha-amylase activity has been proposed to reflect stress-related changes in the autonomic nervous system, and it may be a good choice for monitoring sympathetic nervous system activity in specialized subjects. Hence, it can be concluded that salivary sAA levels can be taken as a predictable as well as reproducible marker for oral SCC or premalignant lesions.

摘要

目的

本研究旨在评估口腔鳞状细胞癌（SCC）患者血浆和唾液中唾液α-淀粉酶（sAA）的水平。同时还确定了sAA的昼夜模式及其对应激的反应。

材料与方法

进行了一项随机临床研究，以评估三个研究组中sAA的唾液和血浆水平，每组包含十名受试者。使用生物检测技术实验室的人α-淀粉酶试剂盒测量血浆和唾液样本中的sAA浓度，并在对照组和试验组之间比较水平。

结果

在所有组中，血浆α-淀粉酶平均水平和唾液α-淀粉酶平均水平均随时间呈现上升趋势，即从早晨到晚上，且在各组中，III组最高，其次是II组，I组最低（III组、II组和I组），在一天中的所有时间III组受试者的平均值均显著更高。

结论

α-淀粉酶是主要的唾液蛋白之一，其分泌受交感神经系统调节。唾液α-淀粉酶活性的测量已被提议用于反映自主神经系统中与应激相关的变化，并且它可能是监测特定受试者交感神经系统活动的一个良好选择。因此，可以得出结论，唾液sAA水平可作为口腔SCC或癌前病变的一个可预测且可重复的标志物。

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