Sinha Sonal, Toshi Toshi, Raj Nikhil, Mankotia Chahat Singh, Kumari Khushboo, Irfan Ahamed Ka, Rangari Priyadarshini
Senior Lecturer, Department of Conservative Dentistry and Endodontics, Dr. B. R. Ambedkar Institute of Dental Sciences and Hospital, Patna, Bihar, India.
Senior lecturer, Department of Periodontics, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S1023-S1026. doi: 10.4103/jpbs.jpbs_252_21. Epub 2022 Jul 13.
The association between cardiovascular diseases and periodontitis had different pathophysiological mechanisms involved. These mechanisms are both inflammatory and microbial. Furthermore, the possible association between two diseases can be explained by common risk factors.
The present trial was carried out to establish a relation between coronary artery disease and periodontitis.
One hundred and twenty-six participants advised for the angiography were included. Periodontists determined the presence of periodontitis in all participants followed by lipid profile, C-reactive protein (CRP) levels, and blood coronary angiography was then performed. The collected data were subjected to the statistical analysis, and the results were formulated.
The level of CRP in participants with and without coronary artery disease was 0.66 ± 1.52 and 0.53 ± 1.01, respectively, which was nonsignificant with a = 0.63. Nonstatistically significant difference was seen in values of cholesterol and blood glucose in participants with and without coronary artery disease ( = 0.28 and = 0.53). The mean tooth loss in participants with coronary artery disease was 14.2 ± 6.4 and in participants with no coronary artery disease was 11.8 ± 6.5, and such difference was statistically significant ( = 0.05).
The present study establishes an association between poor oral health, periodontitis, and coronary artery disease. This study demonstrates that tooth loss which is an important feature of periodontitis is significantly associated with coronary artery disease.
心血管疾病与牙周炎之间的关联涉及不同的病理生理机制。这些机制既有炎症性的,也有微生物性的。此外,两种疾病之间可能的关联可以通过共同的风险因素来解释。
开展本试验以确定冠状动脉疾病与牙周炎之间的关系。
纳入126名建议进行血管造影的参与者。牙周病医生确定所有参与者是否患有牙周炎,随后检测血脂、C反应蛋白(CRP)水平,然后进行冠状动脉血管造影。对收集的数据进行统计分析并得出结果。
患有和未患有冠状动脉疾病的参与者的CRP水平分别为0.66±1.52和0.53±1.01,差异无统计学意义(P=0.63)。患有和未患有冠状动脉疾病的参与者的胆固醇和血糖值差异无统计学意义(P=0.28和P=0.53)。患有冠状动脉疾病的参与者的平均牙齿缺失数为14.2±6.4,未患有冠状动脉疾病的参与者的平均牙齿缺失数为11.8±6.5,这种差异具有统计学意义(P=0.05)。
本研究确立了口腔健康不良、牙周炎与冠状动脉疾病之间的关联。本研究表明,牙齿缺失作为牙周炎的一个重要特征与冠状动脉疾病显著相关。