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本文引用的文献

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Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data.横断面分析牙周炎与心血管疾病的关联:基于韩国基因组与流行病学研究数据。
Int J Environ Res Public Health. 2020 Jul 20;17(14):5237. doi: 10.3390/ijerph17145237.
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Periodontitis and cardiovascular diseases: Consensus report.牙周炎与心血管疾病:共识报告。
J Clin Periodontol. 2020 Mar;47(3):268-288. doi: 10.1111/jcpe.13189. Epub 2020 Feb 3.
3
Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues.牙周炎:一种累及牙齿支持组织的多因素疾病。
J Clin Med. 2019 Jul 31;8(8):1135. doi: 10.3390/jcm8081135.
4
Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017.2007-2017 年全球范围内 2 型糖尿病心血管疾病患病率的系统文献回顾。
Cardiovasc Diabetol. 2018 Jun 8;17(1):83. doi: 10.1186/s12933-018-0728-6.
5
C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review.C反应蛋白(CRP)及其与牙周病的关联:简要综述
J Clin Diagn Res. 2014 Jul;8(7):ZE21-4. doi: 10.7860/JCDR/2014/8355.4646. Epub 2014 Jul 20.
6
Oral health status of CHD and non-CHD adults of Lahore, Pakistan.巴基斯坦拉合尔冠心病及非冠心病成年人的口腔健康状况
J Indian Soc Periodontol. 2011 Jan;15(1):51-4. doi: 10.4103/0972-124X.82273.
7
Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey.刷牙、炎症与心血管疾病风险:来自苏格兰健康调查的结果。
BMJ. 2010 May 27;340:c2451. doi: 10.1136/bmj.c2451.
8
Periodontal microbiota in patients with coronary artery disease measured by real-time polymerase chain reaction: a case-control study.通过实时聚合酶链反应测量的冠状动脉疾病患者的牙周微生物群:一项病例对照研究。
J Periodontol. 2007 Sep;78(9):1724-30. doi: 10.1902/jop.2007.060345.
9
Periodontal disease as a potential risk factor for acute coronary syndromes.
Arq Bras Cardiol. 2006 Nov;87(5):592-6. doi: 10.1590/s0066-782x2006001800007.
10
C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.C反应蛋白及其他循环炎症标志物在冠心病预测中的作用
N Engl J Med. 2004 Apr 1;350(14):1387-97. doi: 10.1056/NEJMoa032804.

口腔面部特征及其与心血管疾病的相关性。

Orofacial Features and Their Correlation in Cardiovascular Diseases.

作者信息

Sinha Sonal, Toshi Toshi, Raj Nikhil, Mankotia Chahat Singh, Kumari Khushboo, Irfan Ahamed Ka, Rangari Priyadarshini

机构信息

Senior Lecturer, Department of Conservative Dentistry and Endodontics, Dr. B. R. Ambedkar Institute of Dental Sciences and Hospital, Patna, Bihar, India.

Senior lecturer, Department of Periodontics, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.

出版信息

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S1023-S1026. doi: 10.4103/jpbs.jpbs_252_21. Epub 2022 Jul 13.

DOI:10.4103/jpbs.jpbs_252_21
PMID:36110682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9469372/
Abstract

BACKGROUND

The association between cardiovascular diseases and periodontitis had different pathophysiological mechanisms involved. These mechanisms are both inflammatory and microbial. Furthermore, the possible association between two diseases can be explained by common risk factors.

AIMS

The present trial was carried out to establish a relation between coronary artery disease and periodontitis.

MATERIALS AND METHODS

One hundred and twenty-six participants advised for the angiography were included. Periodontists determined the presence of periodontitis in all participants followed by lipid profile, C-reactive protein (CRP) levels, and blood coronary angiography was then performed. The collected data were subjected to the statistical analysis, and the results were formulated.

RESULTS

The level of CRP in participants with and without coronary artery disease was 0.66 ± 1.52 and 0.53 ± 1.01, respectively, which was nonsignificant with a = 0.63. Nonstatistically significant difference was seen in values of cholesterol and blood glucose in participants with and without coronary artery disease ( = 0.28 and = 0.53). The mean tooth loss in participants with coronary artery disease was 14.2 ± 6.4 and in participants with no coronary artery disease was 11.8 ± 6.5, and such difference was statistically significant ( = 0.05).

CONCLUSION

The present study establishes an association between poor oral health, periodontitis, and coronary artery disease. This study demonstrates that tooth loss which is an important feature of periodontitis is significantly associated with coronary artery disease.

摘要

背景

心血管疾病与牙周炎之间的关联涉及不同的病理生理机制。这些机制既有炎症性的,也有微生物性的。此外,两种疾病之间可能的关联可以通过共同的风险因素来解释。

目的

开展本试验以确定冠状动脉疾病与牙周炎之间的关系。

材料与方法

纳入126名建议进行血管造影的参与者。牙周病医生确定所有参与者是否患有牙周炎,随后检测血脂、C反应蛋白(CRP)水平,然后进行冠状动脉血管造影。对收集的数据进行统计分析并得出结果。

结果

患有和未患有冠状动脉疾病的参与者的CRP水平分别为0.66±1.52和0.53±1.01,差异无统计学意义(P=0.63)。患有和未患有冠状动脉疾病的参与者的胆固醇和血糖值差异无统计学意义(P=0.28和P=0.53)。患有冠状动脉疾病的参与者的平均牙齿缺失数为14.2±6.4,未患有冠状动脉疾病的参与者的平均牙齿缺失数为11.8±6.5,这种差异具有统计学意义(P=0.05)。

结论

本研究确立了口腔健康不良、牙周炎与冠状动脉疾病之间的关联。本研究表明,牙齿缺失作为牙周炎的一个重要特征与冠状动脉疾病显著相关。