Goutam Manish, Manas Abhigyan, Kashyap Arpita, Verghese Yohan, Jaggi Namita, Pragna K
Department of Prosthodontics, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkand, India.
Department of Dentistry, UP University of Medical Sciences, Saifai, Uttar Pradesh, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S971-S973. doi: 10.4103/jpbs.jpbs_805_21. Epub 2022 Jul 13.
This study aims to evaluate the association of orthodontic tooth movement with the concentration of leptin in gingival crevicular fluid (GCF).
In thirty orthodontic patients, the concentration of leptin was assessed at baseline, 1 h, 24 h, 7 days, and 1 month after application of orthodontic force. Distalized tooth movement was evaluated by measuring the difference on dental casts at baseline and 1 month after force application.
Average concentration of leptin in GCF raises from baseline (T0) to 1 h after application of force (T1). There was a significant association of the overall average concentration of leptin with the degree of tooth movement (correlation coefficient = 0.625).
There was a biphasic change in GCF leptin concentration and significant association between rates of tooth movement with GCF leptin concentration.
本研究旨在评估正畸牙齿移动与龈沟液（GCF）中瘦素浓度之间的关联。
在30名正畸患者中，于施加正畸力后的基线、1小时、24小时、7天和1个月时评估瘦素浓度。通过测量施加力前和施加力1个月后牙模上的差异来评估牙齿远中移动情况。
龈沟液中瘦素的平均浓度从基线（T0）升高至施加力后1小时（T1）。瘦素的总体平均浓度与牙齿移动程度之间存在显著关联（相关系数 = 0.625）。
龈沟液中瘦素浓度呈双相变化，且牙齿移动速率与龈沟液中瘦素浓度之间存在显著关联。
