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印度喀拉拉邦口腔种植医生的抗菌药物处方模式:一项横断面调查。

Antimicrobial Prescription Patterns among Oral Implantologists of Kerala, India: A Cross-Sectional Survey.

作者信息

George Annie Kitty, Narayan Vivek, Joseph Betsy, Balram Bindya, Anil Sukumaran

机构信息

Department of Periodontics, Pushpagiri College of Dental Sciences, Thiruvalla, Kerala, India.

Department of Public Health Dentistry, Government Dental College, Kottayam, Kerala, India.

出版信息

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S712-S718. doi: 10.4103/jpbs.jpbs_744_21. Epub 2022 Jul 13.

DOI:10.4103/jpbs.jpbs_744_21
PMID:36110751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9469451/
Abstract

BACKGROUND AND OBJECTIVES

Antimicrobial resistance is a grave public health concern, and it is important to optimize the use of antimicrobials in dental surgeries. Antimicrobial prescriptions in dental implant placements are often empiric and not guided by consensus or specific guidelines. The aim of this study was to elucidate antibiotic prescribing patterns among oral implantologists. The objectives were to identify the frequency of antimicrobial usage and preferences regarding the perioperative timing of prescriptions, type of antibiotic, dosage, and duration in different implant placement scenarios.

SUBJECTS AND METHODS

An anonymized web-based survey was carried out. Participants were drawn from the lists of oral implantologists from all local branches of the Indian Dental Association in the state of Kerala, India, until the required sample size was met. Responses were recorded using an Internet-based validated questionnaire sent via e-mail to the participants. The questionnaire contained five sections with both open-ended and closed-ended questions.

RESULTS

Among the 93 participants, 59% of the dental implantologists preferred 0.2% povidone-iodine as a preprocedural mouth rinse in the backdrop of the COVID-19 pandemic, and 68% prescribed 0.12%-0.2% chlorhexidine as the postoperative mouth rinse. The majority of the participants (73%) routinely prescribed systemic antibiotics perioperatively during implant placement surgery. Interestingly, while none of the participants preferred a solely preoperative regimen, 92.4% of the dentists in our survey prescribed both pre- and postoperative antibiotics. Antibiotics of choice as the preoperative agents were amoxicillin and amoxicillin plus clavulanic acid. The most preferred postoperative agent was amoxicillin plus clavulanic acid. The popularly reported rationale behind a preoperative antibiotic was to decrease or eliminate local or systemic infections (79%), and the majority of the participants (60%) prescribed postoperative antibiotics to prevent postoperative infection.

CONCLUSIONS

Systemic antibiotic prescriptions in implant placement surgery are not based on currently available evidence. Most oral implantologists who participated in the survey prescribed systemic antibiotics to prevent perioperative infection, even in simple and straightforward implant placements. Specific guidelines need to be generated in complex implant placement situations and implant placement in medically compromised patients to prevent excessive prescriptions.

摘要

背景与目的

抗菌药物耐药性是一个严重的公共卫生问题,在牙科手术中优化抗菌药物的使用非常重要。牙种植手术中的抗菌药物处方往往是经验性的,缺乏共识或具体指南的指导。本研究的目的是阐明口腔种植医生的抗生素处方模式。目标是确定抗菌药物使用的频率以及在不同种植手术场景下关于处方的围手术期时间、抗生素类型、剂量和疗程的偏好。

对象与方法

开展了一项基于网络的匿名调查。参与者从印度喀拉拉邦印度牙科协会所有地方分会的口腔种植医生名单中抽取,直至达到所需样本量。使用通过电子邮件发送给参与者的基于互联网的经过验证的问卷记录回复。问卷包含五个部分,有开放式和封闭式问题。

结果

在93名参与者中,59%的牙种植医生在新冠疫情背景下更倾向于使用0.2%聚维酮碘作为术前口腔含漱液,68%的医生开0.12% - 0.2%氯己定作为术后口腔含漱液。大多数参与者(73%)在种植手术围手术期常规开具全身用抗生素。有趣的是,虽然没有参与者倾向于单纯的术前用药方案,但在我们的调查中92.4%的牙医开具了术前和术后抗生素。术前选用的抗生素是阿莫西林和阿莫西林加克拉维酸。最常用的术后药物是阿莫西林加克拉维酸。术前使用抗生素最常见的理由是减少或消除局部或全身感染(79%),大多数参与者(60%)开具术后抗生素以预防术后感染。

结论

种植手术中的全身用抗生素处方并非基于现有证据。大多数参与调查的口腔种植医生开具全身用抗生素以预防围手术期感染,即使在简单直接的种植手术中也是如此。在复杂种植手术情况以及有医学合并症患者的种植手术中需要制定具体指南,以防止过度处方。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc76/9469451/75ddc5c6dbb6/JPBS-14-712-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc76/9469451/35b5fb5cf8e5/JPBS-14-712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc76/9469451/0d7c8da7309c/JPBS-14-712-g002.jpg
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