Srinivas Sowmya, Ravi M B, Ram Keerthi, Jaishankar Homberhalli H P, Nagaraja Manjunatha S, Gowrav M P, Ramesh Ksv
Department of Prosthodontics, JSS Dental College and Hospital, JSSAHER, Mysore, Karnataka, India.
Department of Prosthodontics, Sri Rajiv Gandhi College of Dental Science and Hospital, Bengaluru, Karnataka, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S595-S599. doi: 10.4103/jpbs.jpbs_653_21. Epub 2022 Jul 13.
Peri-implantitis can be attributed to many underlying causes, one of the chief ones being due to infection caused by oral micro flora and particularly . Antibiotics are administered along with mechanical debridement to control the infection. The side effect of conventional antibiotic therapy and drug resistance has led to the necessity for alternate approaches to handle infections. Natural products are being investigated because of their multi-target activity and structurally different from the normal antibiotics. Propolis a product by Apis Mellifera bees as a wound healing and bone regenerating effect along with antimicrobial effect. One of the important features of Propolis is the chemical properties of Propolis changes with the different locations of procurement. Antimicrobial activity of Hubballi propolis against is not been reported in the literature.
The aim of this study is to evaluate the antimicrobial effect of the Hubballi Propolis against .
The two solvents used for the study were water and 70% Aq ethanol. Minimum inhibitory concentration (MIC), total phenolic contents (TPC), and total flavonoid content (TFC) were tested.
Hubballi Propolis sample showed antimicrobial effect against with MIC range from 0.1 mg/ml to 0.25 mg/ml.
Hubballi Propolis is effective against infection thus may help in treating peri-implantitis. Propolis extracted with water as solvent showed better MIC, higher TPC and TFC than the propolis extracted using alcohol as solvent. This feature is noteworthy as the formulations produced using water extract is favorable than alcohol extract of propolis which irritates the mucosa and hence difficult for its application in dentistry.
种植体周围炎可归因于许多潜在原因，其中一个主要原因是口腔微生物群引起的感染，尤其是……抗生素与机械清创术联合使用以控制感染。传统抗生素治疗的副作用和耐药性导致需要采用替代方法来处理感染。由于天然产物具有多靶点活性且结构与普通抗生素不同，因此正在对其进行研究。蜂胶是蜜蜂生产的一种产品，具有伤口愈合、骨再生作用以及抗菌作用。蜂胶的一个重要特征是其化学性质会随采购地点的不同而变化。文献中尚未报道胡布利蜂胶对……的抗菌活性。
本研究的目的是评估胡布利蜂胶对……的抗菌作用。
本研究使用的两种溶剂是水和70%乙醇水溶液。测试了最低抑菌浓度（MIC）、总酚含量（TPC）和总黄酮含量（TFC）。
胡布利蜂胶样品对……显示出抗菌作用，MIC范围为0.1mg/ml至0.25mg/ml。
胡布利蜂胶对……感染有效，因此可能有助于治疗种植体周围炎。以水为溶剂提取的蜂胶比以酒精为溶剂提取的蜂胶显示出更好的MIC、更高的TPC和TFC。这一特性值得注意，因为使用水提取物生产的制剂比蜂胶酒精提取物更有利，蜂胶酒精提取物会刺激粘膜，因此难以应用于牙科。
