Ganesan Anuradha, Muthukrishnan Arvind, Veeraraghavan Vishnu Priya, Kumar N Gautham
Department of Oral Medicine and Radiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.
Department of Oral Medicine and Radiology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S557-S562. doi: 10.4103/jpbs.jpbs_666_21. Epub 2022 Jul 13.
The aim of the present study was to ascertain the reliability of using salivary glucose in diagnosing and monitoring the blood glucose levels in type 1 diabetic patients and also to evaluate the salivary glucose in fasting and postprandial states and correlate with the blood glucose levels and hemoglobin A1c values.
The study was conducted on 79 Type 1 diabetic patients and 100 healthy controls. The blood and salivary glucose levels were evaluated in both study and control groups using glucose-oxidase peroxidase method.
There was significantly higher level of salivary glucose in diabetics than in controls. There was a positive moderate-to-strong correlation between stimulated and unstimulated salivary glucose to blood glucose in both fasting and postprandial states. The cutoff values for stimulated and unstimulated fasting salivary glucose was 5.8 mg/dl and 5.6 mg/dl, respectively. The cutoff value for stimulated and unstimulated salivary glucose in postprandial state was 10.3 mg/dl and 9.5 mg/dl, respectively.
Salivary glucose appears to be a reliable biofluid to assess the blood glucose levels and can be a reliable alternative to blood glucose in Type 1 diabetes mellitus patients.
本研究的目的是确定使用唾液葡萄糖诊断和监测1型糖尿病患者血糖水平的可靠性，并评估空腹和餐后状态下的唾液葡萄糖水平，以及与血糖水平和糖化血红蛋白值的相关性。
该研究对79名1型糖尿病患者和100名健康对照者进行。研究组和对照组均采用葡萄糖氧化酶过氧化物酶法评估血液和唾液中的葡萄糖水平。
糖尿病患者的唾液葡萄糖水平显著高于对照组。在空腹和餐后状态下，刺激和未刺激的唾液葡萄糖与血糖之间均存在中度至强的正相关。刺激和未刺激的空腹唾液葡萄糖的临界值分别为5.8毫克/分升和5.6毫克/分升。餐后状态下刺激和未刺激的唾液葡萄糖的临界值分别为10.3毫克/分升和9.5毫克/分升。
唾液葡萄糖似乎是评估血糖水平的可靠生物流体，并且可以成为1型糖尿病患者血糖检测的可靠替代方法。
