Gupta Vineet, Kaur Amanpreet
Department of Oral Pathology and Microbiology, Maharaja Ganga Singh Dental College and Research Centre, Sriganganagar, Rajasthan, India.
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):187. doi: 10.4103/jomfp.JOMFP_15_20. Epub 2020 May 8.
The aim of the present study was undertaken to correlate the glucose levels in saliva and blood of diabetic and healthy nondiabetic individuals and to determine the efficacy of saliva as a diagnostic tool.
This was a case-control study.
Forty-five patients previously diagnosed with diabetes mellitus and 45 healthy controls were included in the study. The patients and controls were asked to come to the clinic in the morning, after 8-10 h fasting. At that time, 5 ml of venous blood and unstimulated saliva was collected from both the groups, and 2 h after meal, again, venous blood and unstimulated saliva were collected. The saliva and sera from blood samples were subjected to glucose estimation. Saliva was collected in sterilized vials, and blood was collected in test tubes. Glucose estimation was done by oxidase-peroxidase method.
Pearson's correlation coefficient, Student's -test and paired -test were used for statistical analysis.
Correlation coefficient values show that there is a significant positive correlation between fasting blood and fasting salivary glucose levels and postprandial blood and postprandial salivary glucose levels.
Salivary glucose level estimation can be used as a potential indicator in screening, diagnosis and monitoring of diabetes mellitus. Furthermore, it is an easy and noninvasive method.
本研究旨在关联糖尿病患者和健康非糖尿病个体唾液与血液中的葡萄糖水平，并确定唾液作为诊断工具的有效性。
这是一项病例对照研究。
本研究纳入了45例先前诊断为糖尿病的患者和45例健康对照。患者和对照被要求在禁食8 - 10小时后的早晨前来诊所。此时，两组均采集5毫升静脉血和未刺激的唾液，餐后2小时再次采集静脉血和未刺激的唾液。对血液样本中的唾液和血清进行葡萄糖测定。唾液收集在无菌小瓶中，血液收集在试管中。葡萄糖测定采用氧化酶 - 过氧化物酶法。
采用Pearson相关系数、Student's t检验和配对t检验进行统计分析。
相关系数值表明，空腹血糖与空腹唾液葡萄糖水平以及餐后血糖与餐后唾液葡萄糖水平之间存在显著正相关。
唾液葡萄糖水平测定可作为糖尿病筛查、诊断和监测的潜在指标。此外，它是一种简单且无创的方法。
