Department of Maternal, Child & Adolescent Health, School of Public Health, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Ministry of Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
Ma'anshan Maternal and Child Health Center, Ma'anshan, China.
Eur Child Adolesc Psychiatry. 2024 Oct;33(10):3583-3592. doi: 10.1007/s00787-024-02411-z. Epub 2024 Mar 22.
There has been limited research on maternal anemia affecting children's behavioral development, with a lack of studies focusing on sex differences in this association. Based on the Ma'anshan Birth Cohort, 2132 mother-child pairs were included. Maternal anemia was evaluated based on the hemoglobin concentration and children's behavioral development was assessed by Achenbach Child Behavior Checklist 1.5-5. Binary logistic regression models indicated that compared with children born of mothers without anemia throughout pregnancy, maternal mild anemia during pregnancy or only anemia in the 3rd trimester was associated with increased risks of aggressive behaviors in boys. Maternal mild anemia only in the 2nd trimester was associated with increased risks of attention problems in boys. In girls, maternal mild anemia during pregnancy was associated with increased risks of withdrawn, internalizing problems and total problems. Girls born of mothers with mild anemia only in the 2nd trimester had higher risks of total problems. Maternal mild anemia in both 2nd and 3rd trimesters was associated with increased risks of internalizing problems in girls. Our study identified sex-specific effects of maternal mild anemia during pregnancy on children's behavioral development problems.
关于母体贫血对儿童行为发育的影响，研究有限，且缺乏针对这种关联的性别差异的研究。基于马鞍山出生队列，纳入了 2132 对母婴对子。根据血红蛋白浓度评估母体贫血，采用 Achenbach 儿童行为检查表 1.5-5 评估儿童行为发育。二元逻辑回归模型表明，与孕期母体无贫血的儿童相比，孕期母体轻度贫血或仅孕晚期贫血与男孩攻击行为风险增加相关。仅孕中期母体轻度贫血与男孩注意问题风险增加相关。对于女孩，孕期母体轻度贫血与退缩、内化问题和总问题风险增加相关。仅孕中期母体轻度贫血的女孩总问题风险较高。孕中期和孕晚期母体轻度贫血均与女孩内化问题风险增加相关。我们的研究确定了孕期母体轻度贫血对儿童行为发育问题的性别特异性影响。
