酰胺质子转移成像在脑肿瘤评估中的应用：正常酰胺质子转移信号与异常酰胺质子转移信号值的比较。
Evaluation of Brain Tumors Using Amide Proton Transfer Imaging: A Comparison of Normal Amide Proton Transfer Signal With Abnormal Amide Proton Transfer Signal Value.
机构信息
Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa.
Department of Neurosurgery, Suiseikai Kajikawa Hospital, Hiroshima.
出版信息
J Comput Assist Tomogr. 2023;47(1):121-128. doi: 10.1097/RCT.0000000000001378. Epub 2022 Sep 1.
OBJECTIVE
The aim of the study was to evaluate the relationship of amide proton transfer (APT) signal characteristics in brain tumors and uninvolved brain tissue for patients with glioblastoma and those with brain metastases.
METHODS
Using the mDIXON 3D-APT sequence of the fast spin echo method, an APT image was obtained. The mean APT signal values of tumor core, peritumor edema, ipsilateral normal-appearing white matter (INAWM), and contralateral normal white matter (CNAWM) were obtained and compared between glioblastoma and brain metastases. Receiver operating characteristic curves were used to evaluate parameters for distinguishing between glioblastoma and brain metastases. In addition, the difference and change rate in APT signal values between tumor core and peritumoral edema (PE) and CNAWM were evaluated, respectively.
RESULTS
The APT signal values of glioblastoma were the highest in tumor core (3.41% ± 0.49%), followed by PE (2.24% ± 0.29%), INAWM (1.35% ± 0.15%), and CNAWM (1.26% ± 0.12%, P < 0.001). The APT signal value of brain metastases was the highest in tumor core (2.74% ± 0.34%), followed by PE (1.86% ± 0.35%), INAWM (1.17% ± 0.13%), and CNAWM (1.2% ± 0.09%, P < 0.01). The APT change rate (between PE and CNAWM) was not significantly different at 78% and 56% for glioblastoma and brain metastases, respectively ( P > 0.05).
CONCLUSIONS
Performing APT imaging under the same parameters used in this study may aid in the identification of brain tumors.
目的
本研究旨在评估脑胶质瘤和脑转移瘤患者脑肿瘤和正常脑组织的酰胺质子转移（APT）信号特征之间的关系。
方法
使用快速自旋回波法的 mDIXON 3D-APT 序列获得 APT 图像。获得肿瘤核心、瘤周水肿、同侧正常表现白质（INAWM）和对侧正常白质（CNAWM）的平均 APT 信号值，并比较脑胶质瘤和脑转移瘤之间的差异。使用受试者工作特征曲线评估用于区分脑胶质瘤和脑转移瘤的参数。此外，还评估了肿瘤核心与瘤周水肿（PE）和 CNAWM 之间 APT 信号值的差异和变化率。
结果
脑胶质瘤的 APT 信号值在肿瘤核心最高（3.41%±0.49%），其次是 PE（2.24%±0.29%）、INAWM（1.35%±0.15%）和 CNAWM（1.26%±0.12%，P<0.001）。脑转移瘤的 APT 信号值在肿瘤核心最高（2.74%±0.34%），其次是 PE（1.86%±0.35%）、INAWM（1.17%±0.13%）和 CNAWM（1.2%±0.09%，P<0.01）。脑胶质瘤和脑转移瘤的 APT 变化率（PE 和 CNAWM 之间）分别为 78%和 56%，差异无统计学意义（P>0.05）。
结论
在本研究中使用相同参数进行 APT 成像可能有助于识别脑肿瘤。
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