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Determination of proguanil and its metabolites cycloguanil and 4-chlorophenylbiguanide in plasma, whole blood and urine by high-performance liquid chromatography.

作者信息

Taylor R B, Moody R R, Ochekpe N A

出版信息

J Chromatogr. 1987 May 15;416(2):394-9. doi: 10.1016/0378-4347(87)80526-1.

DOI:10.1016/0378-4347(87)80526-1
PMID:3611272
Abstract
摘要

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1
Determination of proguanil and its metabolites cycloguanil and 4-chlorophenylbiguanide in plasma, whole blood and urine by high-performance liquid chromatography.高效液相色谱法测定血浆、全血和尿液中的氯胍及其代谢物环氯胍和4-氯苯基双胍。
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Improved validated assay for the determination of proguanil and its metabolites in plasma, whole blood, and urine using solid-phase extraction and high-performance liquid chromatography.
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High-performance liquid chromatography of proguanil, cycloguanil and 4-chlorophenylbiguanide using hydrophobic pairing ion and its application to serum assay.采用疏水配对离子对法对氯胍、环氯胍和4-氯苯基双胍进行高效液相色谱分析及其在血清检测中的应用
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5
Determination of proguanil and metabolites in small sample volumes of whole blood stored on filter paper by high-performance liquid chromatography.
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Improved method for the simultaneous determination of proguanil and its metabolites by high-performance liquid chromatography and solid-phase extraction of 100-microl capillary blood samples dried on sampling paper.
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7
Human pharmacokinetics of proguanil and its metabolites.氯胍及其代谢产物的人体药代动力学。
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8
High-performance liquid chromatographic method for the determination of proguanil and cycloguanil in biological fluids.高效液相色谱法测定生物体液中的氯胍和环氯胍。
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Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.采用反相高效液相色谱法同时测定人血浆和尿液中的氯胍及其代谢物，并初步探讨其与基因决定的S-美芬妥因4'-羟化状态的关系。
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10
The multiple dose pharmacokinetics of proguanil.氯胍的多剂量药代动力学。
Br J Clin Pharmacol. 1993 Jun;35(6):653-6. doi: 10.1111/j.1365-2125.1993.tb04197.x.

引用本文的文献

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The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.阿托伐醌和氯胍用于治疗孕晚期孕妇单纯性恶性疟的药代动力学和药效学
Eur J Clin Pharmacol. 2005 Sep;61(8):573-82. doi: 10.1007/s00228-005-0969-7. Epub 2005 Jul 23.
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The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria.阿托伐醌和氯胍在患有急性恶性疟的孕妇中的药代动力学。
Eur J Clin Pharmacol. 2003 Oct;59(7):545-52. doi: 10.1007/s00228-003-0652-9. Epub 2003 Aug 30.
3
Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil.
怀孕和使用口服避孕药会降低氯胍向环氯胍的生物转化。
Eur J Clin Pharmacol. 2003 Oct;59(7):553-7. doi: 10.1007/s00228-003-0651-x. Epub 2003 Aug 30.
4
Evidence for the polymorphic oxidation of debrisoquine and proguanil in a Khmer (Cambodian) population.在高棉（柬埔寨）人群中存在去甲丙咪嗪和氯胍多态性氧化的证据。
Br J Clin Pharmacol. 1995 Aug;40(2):166-9. doi: 10.1111/j.1365-2125.1995.tb05772.x.
5
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.妊娠期间氯胍及其代谢产物的单剂量药代动力学
Eur J Clin Pharmacol. 1993;44(3):247-51. doi: 10.1007/BF00271366.
6
Single dose pharmacokinetics of proguanil and its metabolites in healthy subjects.健康受试者中氯胍及其代谢产物的单剂量药代动力学
Br J Clin Pharmacol. 1987 Dec;24(6):775-80. doi: 10.1111/j.1365-2125.1987.tb03245.x.
7
Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.人体中丙咪嗪代谢为活性代谢物环氯胍的个体间变异性。
Br J Clin Pharmacol. 1989 Jun;27(6):781-7. doi: 10.1111/j.1365-2125.1989.tb03440.x.
8
The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism.人疟原虫预防药（氯胍）的药代动力学及活化：药物代谢变异性的影响
Br J Clin Pharmacol. 1990 Oct;30(4):593-8. doi: 10.1111/j.1365-2125.1990.tb03818.x.
9
In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.双胍类抗疟药在人肝微粒体中的体外代谢：美芬妥英羟化酶（P450 MP）酶作用的证据。
Br J Clin Pharmacol. 1990 Aug;30(2):287-91. doi: 10.1111/j.1365-2125.1990.tb03777.x.
10
The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study.双胍类抗疟药氯胍的激活与美芬妥因氧化多态性共分离——一项分组研究。
Br J Clin Pharmacol. 1991 Jun;31(6):689-92. doi: 10.1111/j.1365-2125.1991.tb05594.x.