Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, USA.
Neuroimage. 2022 Nov;263:119628. doi: 10.1016/j.neuroimage.2022.119628. Epub 2022 Sep 13.
Interactions between the brain and the stomach shape both cognitive and digestive functions. Recent human studies report spontaneous synchronization between brain activity and gastric slow waves in the resting state. However, this finding has not been replicated in any animal models. The neural pathways underlying this apparent stomach-brain synchrony is also unclear. Here, we performed functional magnetic resonance imaging while simultaneously recording body-surface gastric slow waves from anesthetized rats in the fasted vs. postprandial conditions and performed a bilateral cervical vagotomy to assess the role of the vagus nerve. The coherence between brain fMRI signals and gastric slow waves was found in a distributed "gastric network", including subcortical and cortical regions in the sensory, motor, and limbic systems. The stomach-brain coherence was largely reduced by the bilateral vagotomy and was different between the fasted and fed states. These findings suggest that the vagus nerve mediates the spontaneous coherence between brain activity and gastric slow waves, which is likely a signature of real-time stomach-brain interactions. However, its functional significance remains to be established.
大脑和胃之间的相互作用塑造了认知和消化功能。最近的人类研究报告称，在静息状态下大脑活动和胃慢波之间存在自发同步。然而，这一发现尚未在任何动物模型中得到复制。这种明显的胃-脑同步的神经通路也不清楚。在这里，我们在禁食和餐后条件下对麻醉大鼠进行了功能磁共振成像，同时记录了体表胃慢波，并进行了双侧颈迷走神经切断术以评估迷走神经的作用。在包括感觉、运动和边缘系统的皮质和皮质下区域的分布式“胃网络”中发现了脑 fMRI 信号与胃慢波之间的相干性。双侧迷走神经切断术大大降低了胃-脑的相干性，并且在禁食和进食状态之间存在差异。这些发现表明，迷走神经介导了大脑活动和胃慢波之间的自发同步，这可能是实时胃-脑相互作用的特征。然而，其功能意义仍有待确定。
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