Acosta-Mejia Martha Teresa, Villalobos Nelson
Área Académica de Nutrición, Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda La Concepción, Sn Agustin Tlaxiaca, Estado de Hidalgo 42160, Mexico.
Academia de Fisiología, Escuela Superior de Medicina, Instituto Politécnico, Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, Ciudad de Mexico 11340, Mexico.
Diagnostics (Basel). 2023 Jul 18;13(14):2394. doi: 10.3390/diagnostics13142394.
Parkinson's disease (PD) is one of the leading neurodegenerative disorders. It is considered a movement disorder, although it is accepted that many nonmotor symptoms accompany the classic motor symptoms. PD exhibits heterogeneous and overlaying clinical symptoms, and the overlap of motor and nonmotor symptoms complicates the clinical diagnosis and management. Loss of modulation secondary to the absence of dopamine due to degeneration of the substantia nigra compacta produces changes in firing rates and patterns, oscillatory activity, and higher interneuronal synchronization in the basal ganglia-thalamus-cortex and nigrovagal network involvement in motor and nonmotor symptoms. These neurophysiological changes can be monitored by electrophysiological assessment. The purpose of this review was to summarize the results of neurophysiological changes, especially in the network oscillation in the beta-band level associated with parkinsonism, and to discuss the use of these methods to optimize the diagnosis and management of PD.
帕金森病（PD）是主要的神经退行性疾病之一。它被认为是一种运动障碍，尽管人们公认许多非运动症状伴随经典的运动症状出现。帕金森病表现出异质性和重叠性的临床症状，运动和非运动症状的重叠使临床诊断和管理变得复杂。由于黑质致密部变性导致多巴胺缺乏继发的调节丧失，会在基底神经节 - 丘脑 - 皮质以及参与运动和非运动症状的黑质迷走神经网络中产生放电频率和模式、振荡活动以及更高的神经元间同步性的变化。这些神经生理变化可以通过电生理评估进行监测。本综述的目的是总结神经生理变化的结果，特别是与帕金森症相关的β波段水平的网络振荡，并讨论使用这些方法来优化帕金森病的诊断和管理。
