Rubin E H, Morris J C, Berg L
J Am Geriatr Soc. 1987 Aug;35(8):721-5. doi: 10.1111/j.1532-5415.1987.tb06349.x.
Passive, agitated, and self-centered behavioral changes were noted on initial evaluation in two-thirds, one-third, and one-third, respectively, of subjects with mild senile dementia of the Alzheimer's type (SDAT). Over a 50-month follow-up period, the percentage of patients who exhibited agitated and self-centered behaviors doubled. The percentage of subjects who demonstrated all three behavioral changes increased from 11% at entry to the study (mild SDAT) to over 50% when the dementia had reached a severe stage. The presence of personality changes at a mild stage of dementia did not predispose subjects to more rapid progression to a more advanced stage of illness.
在对三分之二、三分之一和三分之一的轻度阿尔茨海默型老年性痴呆（SDAT）患者进行初次评估时，分别观察到被动、烦躁和以自我为中心的行为变化。在50个月的随访期内，表现出烦躁和以自我为中心行为的患者百分比增加了一倍。表现出所有三种行为变化的受试者百分比从研究开始时（轻度SDAT）的11%增加到痴呆症达到严重阶段时的50%以上。痴呆症轻度阶段出现人格变化并不会使受试者更容易快速发展到疾病的更晚期。
