Meiklejohn G, Hall H
J Am Geriatr Soc. 1987 Aug;35(8):742-6. doi: 10.1111/j.1532-5415.1987.tb06352.x.
An explosive outbreak of Influenza A (H3N2) occurred during early February 1985 among the 55 residents of a nursing home in Douglas, Wyoming. Thirty of the 55 (55%) had febrile respiratory illnesses. Thirty-six (65%) had received influenza vaccine. The attack rate was 84% in unvaccinated and 39% in vaccinated persons. Vaccine efficacy was estimated to be 54%. There were eight cases of pneumonia in unvaccinated and four in vaccinated persons, three deaths in unvaccinated and one death in vaccinated persons. Complement fixation and hemagglutination inhibition tests on sera from 47 residents confirmed the diagnosis of Influenza A in the great majority of individuals, and furthermore showed very low levels of antibody for the Influenza A H1N1 and Influenza B components of the vaccine.
1985年2月初，怀俄明州道格拉斯一家养老院的55名居民中爆发了甲型（H3N2）流感疫情。55人中有30人（55%）出现发热性呼吸道疾病。36人（65%）接种了流感疫苗。未接种疫苗者的发病率为84%，接种疫苗者为39%。疫苗效力估计为54%。未接种疫苗者中有8例肺炎，接种疫苗者中有4例；未接种疫苗者中有3人死亡，接种疫苗者中有1人死亡。对47名居民血清进行的补体结合试验和血凝抑制试验证实，绝大多数人感染了甲型流感，此外还显示，针对疫苗中甲型H1N1流感和乙型流感成分的抗体水平非常低。
