University of Strasbourg, LIVE UMR 7362 CNRS (Laboratoire Image Ville Environnement), Strasbourg, France.
Department of Obstetrics and Gynaecology, University Hospitals Strasbourg, Strasbourg, France.
BMJ Open. 2022 Sep 17;12(9):e058883. doi: 10.1136/bmjopen-2021-058883.
A growing number of international studies have highlighted the adverse consequences of lived experience in the first thousand days of pregnancy and early life on the probability of stillbirth, child mortality, inadequate growth and healthy development during both childhood and adulthood. The lived experience of the fetus inside the womb and at the birth is strongly related to both maternal health during pregnancy and maternal exposure to a set of environmental factors known as 'exposome' characteristics, which include environmental exposure, health behaviours, living conditions, neighbourhood characteristics and socioeconomic profile. The aim of our project is to explore the relationships between exposome characteristics and the health status of pregnant women and their newborns. We are particularly interested in studying the relationships between the social inequality of adverse pregnancy outcomes and (1) short-term exposure to atmospheric pollution (MobiFem project) and (2) pregnancy lifestyle (EnviFem project).
Ours is a prospective, observational and multisite cohort study of pregnant women, involving one teaching hospital across two sites in the Strasbourg metropolitan area.The research team at University Hospital of Strasbourg (HUS) Health collects data on outcomes and individual characteristics from pregnancy registries, clinical records data and questionnaires administered via email to study participants. Recruitment began in February 2021 and will be complete by December 2021. Participants are recruited from first trimester antenatal ultrasound examinations (conducted on weekdays across both sites); each woman meeting our inclusion criteria enters the cohort at the end of her first trimester. Study participants receive a total of three online questionnaires covering sociodemographic characteristics, travel behaviour patterns and lifestyle. Participants complete these questionnaires at recruitment, during the second and third trimester. The level of personal exposure to air pollution is characterised using a dynamic spatiotemporal trajectory model that describes the main daily movements of pregnant women and the time spent in each place frequented. Univariate, multilevel and Bayesian model will be used to investigate the relationships between exposome characteristics and the health status of pregnant women and their newborns.
Our research was approved by the Commission de Protection des Personnes (CPP) Ile de France VI (Paris) on 9 December 2020 (File reference No. 20.09.15.41703 ID RCB: 2020-A02580-39 and No. 20 080-42137 IDRCB 2020-A02581-38). The Agence Nationale de Sécurité du Médicament was informed of it on 15 December 2020. Findings from the study will be disseminated through publications and international conferences and through presentation at meetings with local stakeholders, researchers and policy-makers.
NCT04705272, NCT04725734.
越来越多的国际研究强调了妊娠和生命早期的生活经历对死产、儿童死亡率、生长发育不足以及儿童和成年期健康发展的概率的不利影响。胎儿在子宫内和出生时的生活经历与孕妇在怀孕期间的健康状况以及母体暴露于一组称为“暴露组”特征的环境因素密切相关，其中包括环境暴露、健康行为、生活条件、社区特征和社会经济状况。我们项目的目的是探索暴露组特征与孕妇及其新生儿健康状况之间的关系。我们特别感兴趣的是研究（1）短期大气污染（MobiFem 项目）和（2）妊娠生活方式（EnviFem 项目）与不良妊娠结局的社会不平等之间的关系。
我们的研究是一项针对孕妇的前瞻性、观察性和多地点队列研究，涉及斯特拉斯堡大都市区的两家教学医院。斯特拉斯堡大学医院（HUS）健康研究团队从妊娠登记处、临床记录数据和通过电子邮件向研究参与者发送的问卷中收集结局和个体特征数据。招募工作于 2021 年 2 月开始，将于 2021 年 12 月完成。通过第一孕期超声检查（在两个地点的工作日进行）招募参与者；符合纳入标准的每位女性在第一孕期结束时进入队列。研究参与者总共收到三份涵盖社会人口特征、出行行为模式和生活方式的在线问卷。参与者在招募时、第二孕期和第三孕期填写这些问卷。使用描述孕妇主要日常活动和每个常去地点停留时间的动态时空轨迹模型来描述个人对空气污染的暴露水平。将使用单变量、多层次和贝叶斯模型来研究暴露组特征与孕妇及其新生儿健康状况之间的关系。
我们的研究于 2020 年 12 月 9 日获得巴黎法兰西岛六区保护人委员会（CPP）的批准（文件参考号为 20.09.15.41703 ID RCB：2020-A02580-39 和 202080-42137 IDRCB 2020-A02581-38）。2020 年 12 月 15 日，国家药品安全局（ANSM）获悉了这一情况。研究结果将通过出版物和国际会议以及在与当地利益相关者、研究人员和政策制定者举行的会议上介绍来传播。
NCT04705272，NCT04725734。
