采用theta爆发式刺激的重复经颅磁刺激治疗老年抑郁症：一项随机、双盲、对照试验的研究方案。
Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: Study protocol for a randomized, double-blind, controlled trial.
作者信息
Valiengo Leandro, Pinto Bianca S, Marinho Kalian A P, Santos Leonardo A, Tort Luara C, Benatti Rafael G, Teixeira Bruna B, Miranda Cristiane S, Cardeal Henriette B, Suen Paulo J C, Loureiro Julia C, Vaughan Renata A R, Dini Mattar Roberta A M P F, Lessa Maíra, Oliveira Pedro S, Silva Valquíria A, Gattaz Wagner Farid, Brunoni André R, Forlenza Orestes Vicente
机构信息
Interdisciplinary Neuromodulation Service (SIN), Department and Institute of Psychiatry, Hospital das Clínicas HCFMUSP, Faculty of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Laboratório de Neurociências (LIM-27), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
出版信息
Front Hum Neurosci. 2022 Aug 31;16:941981. doi: 10.3389/fnhum.2022.941981. eCollection 2022.
INTRODUCTION
Transcranial magnetic stimulation (TMS) is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation (TBS) is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate the efficacy of TBS in geriatric depression.
CLINICAL TRIAL REGISTRATION
[https://clinicaltrials.gov/ct2/], identifier [NCT04842929].
引言
经颅磁刺激（TMS）是一种成熟的抑郁症治疗方法，多项荟萃分析证明了其有效性。theta爆发刺激（TBS）是TMS的一种改良方法，具有相似的疗效且疗程更短。老年人群有多种合并症且抑郁症患病率高，但专门针对该年龄组进行的临床试验较少。TBS可能是该人群的一种选择，具有副作用少且无药物相互作用的优点。因此，我们的目的是研究TBS在老年抑郁症中的疗效。
临床试验注册
[https://clinicaltrials.gov/ct2/]，标识符 [NCT04842929]。
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