Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.
Front Immunol. 2022 Sep 2;13:969399. doi: 10.3389/fimmu.2022.969399. eCollection 2022.
Pregnane X receptor (PXR, NR1I2), a prototypical member of the nuclear receptor superfamily, has been implicated in various processes including metabolism, immune response, and inflammation. The immune system is made up of many interdependent parts, including lymphoid organs, cells, and cytokines, which play important roles in identifying, repelling, and eliminating pathogens and other foreign chemicals. An impaired immune system could contribute to various physical dysfunction, including severe infections, allergic diseases, autoimmune disorders, and other inflammatory diseases. Recent studies revealed the involvement of PXR in the pathogenesis of immune disorders and inflammatory responses. Thus, the aim of this work is to review and discuss the advances in research associated with PXR on immunity and inflammatory diseases and to provide insights into the development of therapeutic interventions of immune disorders and inflammatory diseases by targeting PXR.
妊娠相关 X 受体 (PXR，NR1I2) 是核受体超家族的典型成员，与多种过程相关，包括代谢、免疫反应和炎症。免疫系统由许多相互依存的部分组成，包括淋巴器官、细胞和细胞因子，它们在识别、排斥和消除病原体和其他外来化学物质方面发挥着重要作用。免疫系统受损可能导致各种身体功能障碍，包括严重感染、过敏疾病、自身免疫性疾病和其他炎症性疾病。最近的研究表明 PXR 参与了免疫紊乱和炎症反应的发病机制。因此，本工作的目的是综述和讨论与 PXR 相关的免疫和炎症性疾病研究进展，并为通过靶向 PXR 开发免疫紊乱和炎症性疾病的治疗干预措施提供思路。
