Tong Tao, Wang Ya-Nan, Zhang Cheng-Mei, Kang Seong-Gook
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Guizhou Academy of Testing and Analysis, Guiyang 550000, China.
Chin Herb Med. 2021 Aug 5;13(4):541-548. doi: 10.1016/j.chmed.2021.08.003. eCollection 2021 Oct.
To evaluate antihypertensive and antioxidant activities of root (AHR) fermented with , , and .
The novel fermented AHR products using , s, and were developed and ACE inhibitory activity, DPPH radical scavenging activity, hydroxyl radical scavenging activity, superoxide anion radical scavenging activity, total phenolic content, and total thiosulfinate content were determined. The antihypertensive and antioxidant effects of fermented AHR were further investigated in spontaneously hypertensive rats (SHRs).
Administration of fermented AHR to SHRs had an attenuating effect on both diastolic and systolic blood pressure. The SHRs treated with fermented AHR showed lower plasma ACE activity and higher plasma NO levels. Furthermore, fermented AHR administration led to parallel improvements in plasma oxidative stress biomarkers in SHRs.
Our results highlight the potential usefulness of fermented AHR for the prevention of hypertension.
评估用[具体物质1]、[具体物质2]和[具体物质3]发酵的[植物名称]根(AHR)的降压和抗氧化活性。
开发了使用[具体物质1]、[具体物质2]和[具体物质3]的新型发酵AHR产品,并测定了其对血管紧张素转换酶(ACE)的抑制活性、对1,1-二苯基-2-三硝基苯肼(DPPH)自由基的清除活性、对羟基自由基的清除活性、对超氧阴离子自由基的清除活性、总酚含量和总硫代亚磺酸盐含量。在自发性高血压大鼠(SHRs)中进一步研究了发酵AHR的降压和抗氧化作用。
给SHRs施用发酵AHR对舒张压和收缩压均有减轻作用。用发酵AHR处理的SHRs血浆ACE活性较低,血浆一氧化氮(NO)水平较高。此外,施用发酵AHR使SHRs的血浆氧化应激生物标志物同时得到改善。
我们的结果突出了发酵AHR在预防高血压方面的潜在用途。