Kelbaek H, Hartling O J, Skagen K, Munck O, Henriksen O, Godtfredsen J
J Nucl Med. 1987 Aug;28(8):1330-4.
A technique for noninvasive determination of cardiac output by aid of first-pass radionuclide cardiography is described. After intravenous injection of 10-15 mCi technetium-99m-(99mTc) labeled red blood cells the method requires acquisition of a first passage time-activity curve recorded with a gamma camera over the left ventricle, the background corrected left ventricular count rate recorded after complete mixing of the tracer in the circulation, and determination of the distribution volume of the tracer. The method was applied in 14 patients with heart disease of various origins and evaluated against the conventional tracer dilution technique with arterial sampling of blood activity. Cardiac output determinations by external counting ranged from 2.30 to 8.56 l/min, mean +/- s.d. 4.50 +/- 1.66 l/min and by arterial blood sampling from 1.88 to 8.96 l/min, mean +/- s.d. 4.52 +/- 1.71 l/min. An excellent correlation was demonstrated between the two techniques, r = 0.978 (p less than 0.001). When no background subtraction was applied to the left ventricular counts at equilibrium, radionuclide cardiac output values were approximately 40% higher than those obtained by arterial sampling. The new first-pass radionuclide cardiographic technique may prove a useful tool in the noninvasive evaluation of cardiac function, especially in patients with arrhythmias and/or valvular incompetence.
本文描述了一种借助首次通过放射性核素心动图非侵入性测定心输出量的技术。静脉注射10 - 15毫居里的锝- 99m（99mTc）标记的红细胞后，该方法需要采集用γ相机记录的左心室首次通过时间-活度曲线、示踪剂在循环中完全混合后记录的背景校正左心室计数率以及测定示踪剂的分布容积。该方法应用于14例不同病因的心脏病患者，并与通过动脉血样采集的传统示踪剂稀释技术进行比较评估。通过外部计数测定的心输出量范围为2.30至8.56升/分钟，平均±标准差为4.50±1.66升/分钟，通过动脉血样采集测定的心输出量范围为1.88至8.96升/分钟，平均±标准差为4.52±1.71升/分钟。两种技术之间显示出极好的相关性，r = 0.978（p < 0.001）。当在平衡时对左心室计数不进行背景扣除时，放射性核素心输出量值比通过动脉血样采集获得的值高约40%。新的首次通过放射性核素心动图技术可能证明是评估心脏功能的一种有用工具，特别是在患有心律失常和/或瓣膜功能不全的患者中。
