Crean P A, Pratt T, Davies G J, Myers M, Lavender P, Maseri A
Br J Radiol. 1986 Mar;59(699):209-15. doi: 10.1259/0007-1285-59-699-209.
To investigate the distribution of organ blood flow in patients we have developed a method of quantitating the whole-body fractional distribution of 99Tcm-labelled microspheres. The microspheres were injected into the left ventricle in nine patients with normal cardiac indices (greater than 3 1/min/m2; Group A) and 11 patients with low cardiac indices (less than 2.51 l/min/m2; Group B). The fractional organ content of the total injected dose was estimated following correction for geometry and transmission using a gamma camera. Cerebral blood flow was 579 +/- 163 ml/min (mean +/- SD) in Group A and 593 +/- 158 ml/min in Group B (p not significant (NS)). Myocardial flow in Group A was 266 +/- 82 ml/min and in Group B was 237 +/- 57 ml/min (p, NS). Total renal blood flow was 749 +/- 161 ml/min in Group A and 614 +/- 181 ml/min in Group B (p less than 0.01). There was a negative correlation between cardiac index and the percentage of the cardiac output distributed to brain (r = -0.70, p less than 0.01), heart (r = -0.67, p less than 0.01) and kidneys (r = -0.47), p less than 0.05). Low output cardiac failure is, therefore, associated with relative preservation of cerebral and myocardial blood flow and, to a lesser extent, of renal flow. A similar technique using dual labelling would allow an accurate estimation in individual patients, of the change in organ blood flow associated with transient alterations in cardiac output states.
为了研究患者体内器官血流的分布情况，我们开发了一种定量99锝标记微球全身分数分布的方法。将微球注入9名心脏指数正常（大于3升/分钟/平方米；A组）和11名心脏指数较低（小于2.51升/分钟/平方米；B组）的患者的左心室。使用γ相机在对几何形状和透射进行校正后，估算注入总剂量的器官分数含量。A组的脑血流量为579±163毫升/分钟（平均值±标准差），B组为593±158毫升/分钟（p无显著性差异（NS））。A组的心肌血流量为266±82毫升/分钟，B组为237±57毫升/分钟（p，NS）。A组的总肾血流量为749±161毫升/分钟，B组为614±181毫升/分钟（p<0.01）。心脏指数与分配到脑的心输出量百分比（r=-0.70，p<0.01）、心脏（r=-0.67，p<0.01）和肾脏（r=-0.47，p<0.05）之间存在负相关。因此，低输出量心力衰竭与脑和心肌血流的相对保留以及程度较轻的肾血流保留有关。使用双标记的类似技术将能够准确估计个体患者中心输出量状态的短暂改变所伴随的器官血流变化。
