DeGiorgio C M, Correale J D, Gott P S, Ginsburg D L, Bracht K A, Smith T, Boutros R, Loskota W J, Rabinowicz A L
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033, USA.
Neurology. 1995 Jun;45(6):1134-7. doi: 10.1212/wnl.45.6.1134.
Neuron-specific enolase (NSE) is a sensitive marker of brain injury after stroke, global ischemia, and coma. We report changes in serum NSE (s-NSE) in 19 patients who sustained status epilepticus. s-NSE peaked within 24 to 48 hours after status epilepticus. The mean peak s-NSE level for the entire group was elevated compared with the levels for normal controls (24.87 ng/ml versus 5.36 ng/ml, p = 0.0001) and for epileptic controls (24.87 ng/ml versus 4.61 ng/ml, p = 0.0001). The mean peak s-NSE level for the 11 subjects without an acute neurologic insult (15.44 ng/ml) was also significantly increased compared with levels for normal and epileptic controls. Further, s-NSE was significantly correlated with outcome and duration. We conclude that s-NSE is a promising in vivo marker of brain injury in status epilepticus and warrants further study in larger populations.
神经元特异性烯醇化酶（NSE）是中风、全脑缺血和昏迷后脑损伤的敏感标志物。我们报告了19例癫痫持续状态患者血清NSE（s-NSE）的变化。s-NSE在癫痫持续状态后24至48小时内达到峰值。与正常对照组（24.87 ng/ml对5.36 ng/ml，p = 0.0001）和癫痫对照组（24.87 ng/ml对4.61 ng/ml，p = 0.0001）相比，整个组的平均s-NSE峰值水平升高。11例无急性神经损伤受试者的平均s-NSE峰值水平（15.44 ng/ml）与正常和癫痫对照组相比也显著升高。此外，s-NSE与预后和病程显著相关。我们得出结论，s-NSE是癫痫持续状态脑损伤有前景的体内标志物，值得在更大人群中进一步研究。
