Division of Urology, Department of Surgery, The University of Hong Kong, Hong Kong, China.
Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Asian J Androl. 2023 May-Jun;25(3):345-349. doi: 10.4103/aja202264.
The long-term survival outcomes of radical prostatectomy (RP) in Chinese prostate cancer (PCa) patients are poorly understood. We conducted a single-center, retrospective analysis of patients undergoing RP to study the prognostic value of pathological and surgical information. From April 1998 to February 2022, 782 patients undergoing RP at Queen Mary Hospital of The University of Hong Kong (Hong Kong, China) were included in our study. Multivariable Cox regression analysis and Kaplan-Meier analysis with stratification were performed. The 5-year, 10-year, and 15-year overall survival (OS) rates were 96.6%, 86.8%, and 70.6%, respectively, while the 5-year, 10-year, and 15-year PCa-specific survival (PSS) rates were 99.7%, 98.6%, and 97.8%, respectively. Surgical International Society of Urological Pathology PCa grades (ISUP Grade Group) ≥4 was significantly associated with poorer PSS (hazard ratio [HR] = 8.52, 95% confidence interval [CI]: 1.42-51.25, P = 0.02). Pathological T3 stage was not significantly associated with PSS or OS in our cohort. Lymph node invasion and extracapsular extension might be associated with worse PSS (HR = 20.30, 95% CI: 1.22-336.38, P = 0.04; and HR = 7.29, 95% CI: 1.22-43.64, P = 0.03, respectively). Different surgical approaches (open, laparoscopic, or robotic-assisted) had similar outcomes in terms of PSS and OS. In conclusion, we report the longest timespan follow-up of Chinese PCa patients after RP with different approaches.
根治性前列腺切除术（RP）治疗中国前列腺癌（PCa）患者的长期生存结果尚不清楚。我们对接受 RP 治疗的患者进行了单中心回顾性分析，以研究病理和手术信息的预后价值。1998 年 4 月至 2022 年 2 月，共有 782 例在香港大学玛丽医院（中国香港）接受 RP 的患者纳入我们的研究。进行多变量 Cox 回归分析和 Kaplan-Meier 分析及分层。5 年、10 年和 15 年的总生存率（OS）分别为 96.6%、86.8%和 70.6%，5 年、10 年和 15 年的 PCa 特异性生存率（PSS）分别为 99.7%、98.6%和 97.8%。国际泌尿病理协会前列腺癌分级（ISUP 分级组）≥4 与较差的 PSS 显著相关（风险比 [HR] = 8.52，95%置信区间 [CI]：1.42-51.25，P = 0.02）。病理 T3 期在本队列中与 PSS 或 OS 无显著相关性。淋巴结侵犯和包膜外侵犯可能与较差的 PSS 相关（HR = 20.30，95%CI：1.22-336.38，P = 0.04；和 HR = 7.29，95%CI：1.22-43.64，P = 0.03）。不同的手术方式（开放、腹腔镜或机器人辅助）在 PSS 和 OS 方面的结果相似。总之，我们报告了不同手术方式治疗中国 PCa 患者 RP 后最长时间的随访结果。
