Psychology Department, University of Arizona, Tucson, AZ 85721, United States.
Center for Vital Longevity, University of Texas at Dallas, Dallas, TX 75235, United States.
Cereb Cortex. 2023 Apr 4;33(8):4542-4552. doi: 10.1093/cercor/bhac360.
Memory retrieval effects in the striatum are well documented and robust across experimental paradigms. However, the functional significance of these effects, and whether they are moderated by age, remains unclear. We used functional magnetic resonance imaging paired with an associative recognition task to examine retrieval effects in the striatum in a sample of healthy young, middle-aged, and older adults. We identified anatomically segregated patterns of enhanced striatal blood oxygen level-dependent (BOLD) activity during recollection- and familiarity-based memory judgments. Successful recollection was associated with enhanced BOLD activity in bilateral putamen and nucleus accumbens, and neither of these effects were reliably moderated by age. Familiarity effects were evident in the head of the caudate nucleus bilaterally, and these effects were attenuated in middle-aged and older adults. Using psychophysiological interaction analyses, we observed a monitoring-related increase in functional connectivity between the caudate and regions of the frontoparietal control network, and between the putamen and bilateral retrosplenial cortex and intraparietal sulcus. In all instances, monitoring-related increases in cortico-striatal connectivity were unmoderated by age. These results suggest that the striatum, and the caudate in particular, couples with the frontoparietal control network to support top-down retrieval-monitoring operations, and that the strength of these inter-regional interactions is preserved in later life.
纹状体中的记忆检索效应在各种实验范式中都有很好的记录，而且非常可靠。然而，这些效应的功能意义，以及它们是否受年龄影响，仍然不清楚。我们使用功能磁共振成像结合联想识别任务，在一组健康的年轻、中年和老年成年人中检查纹状体中的检索效应。我们确定了在回忆和熟悉度记忆判断中纹状体血氧水平依赖（BOLD）活性增强的解剖分离模式。成功的回忆与双侧壳核和伏隔核的 BOLD 活性增强有关，而这些效应都不受年龄的可靠调节。熟悉度效应在双侧尾状核头部明显，而这些效应在中年和老年成年人中减弱。使用心理生理交互分析，我们观察到尾状核和额顶控制网络区域之间以及壳核和双侧扣带回和顶内沟之间的功能连接监测相关增加。在所有情况下，监测相关的皮质纹状体连接增加不受年龄影响。这些结果表明，纹状体，特别是尾状核，与额顶控制网络耦合，以支持自上而下的检索监测操作，并且这些区域间相互作用的强度在以后的生活中得以保留。
