Department of Ophthalmology, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.
Sci Rep. 2022 Sep 20;12(1):15702. doi: 10.1038/s41598-022-19785-2.
The lamina cribrosa (LC) becomes shallower as intraocular pressure (IOP) decreases after trabeculectomy. The LC in eyes with exfoliation syndrome has distinctive properties in the connective tissue and extracellular matrix, but how these affect the changes in LC depth in response to IOP reduction after trabeculectomy is unknown. We analyzed pre- and postoperative spectral-domain optical coherence tomography of exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) patients who underwent trabeculectomy and investigated whether LC depth differed between XFG and POAG eyes after trabeculectomy. In total, 30 XFG eyes and 30 visual field mean deviation-matched POAG eyes were included. LC depth was determined at an average of 3.9 months after trabeculectomy. Postoperatively, the LC depth became shallower and the BMO-MRW became thicker in both XFG and POAG eyes. XFG eyes showed lesser amount of LC depth shallowing than POAG eyes. Greater preoperative LC depth, lower postoperative IOP, and absence of XFG were all associated with a greater degree of postoperative LC depth shallowing. These findings suggest that the LC of XFG eyes may inherently possess the distinctive properties of the connective tissue and extracellular matrix contained within it, which could affect the LC response to the reduction in IOP after trabeculectomy.
小梁切除术可降低眼内压（IOP），小梁切除术可降低眼内压（IOP），小梁切除术可降低眼内压（IOP），小梁切除术可降低眼内压（IOP），小梁切除术可降低眼内压（IOP），小梁切除术可降低眼内压（IOP），小梁切除术可降低眼内压（IOP），小梁切除术可降低眼内压（IOP）。筛板（LC）变得更浅。剥脱综合征患者的 LC 在结缔组织和细胞外基质中具有独特的特性，但这些特性如何影响 LC 深度对小梁切除术后 IOP 降低的反应尚不清楚。我们分析了接受小梁切除术的剥脱性青光眼（XFG）和原发性开角型青光眼（POAG）患者的术前和术后频域光相干断层扫描，并研究了小梁切除术后 XFG 眼和 POAG 眼的 LC 深度是否存在差异。共纳入 30 例 XFG 眼和 30 例视野平均偏差匹配的 POAG 眼。平均在小梁切除术后 3.9 个月确定 LC 深度。术后，LC 深度变浅，BMO-MRW 变厚，XFG 和 POAG 眼均如此。XFG 眼的 LC 深度变浅程度低于 POAG 眼。术前 LC 深度较大、术后眼压较低以及无 XFG 均与术后 LC 深度变浅程度较大相关。这些发现表明，XFG 眼的 LC 可能固有地具有其中包含的结缔组织和细胞外基质的独特特性，这可能影响 LC 对小梁切除术后 IOP 降低的反应。
