Glaucoma, Singapore Eye Research Institute, Singapore.
Department of Biomedical Engineering, National University of Singapore, Singapore.
Br J Ophthalmol. 2021 Mar;105(3):367-373. doi: 10.1136/bjophthalmol-2020-315840. Epub 2020 May 20.
To investigate the determinants of lamina cribrosa depth (LCD) in healthy eyes of Chinese and Indian Singaporean adults.
The optic nerve head (ONH) of the right eye of 1396 subjects (628 Chinese and 768 Indian subjects) was imaged with optical coherence tomography (OCT, Spectralis, Heidelberg, Germany). LCD was defined as the distance from the Bruch's membrane opening (LCD-BMO) or the peripapillary sclera (LCD-PPS) reference plane to the laminar surface. A linear regression model was used to evaluate the relationship between the LCD and its determinants.
Both LCDs were significantly different between the two races (LCD-BMO: 421.95 (95% CI 365.32 to 491.79) µm in Chinese vs 430.39 (367.46-509.81) µm in Indians, p=0.021; and LCD-PPS: 353.34 (300.98-421.45) µm in Chinese vs 376.76 (313.39-459.78) µm in Indians, p<0.001). In the multivariable regression analysis, the LCD-PPS of the whole cohort was independently associated with females (β=-31.93, p<0.001), Indians subjects (β=21.39, p=0.004) (Chinese as the reference), axial length (Axl) (β=-6.68, p=0.032), retinal nerve fibre layer thickness (RNFL) (β=0.71, p=0.019), choroidal thickness (ChT) (β=0.41, p<0.001), vertical cup disc ratio (VCDR) (β=24.42, p<0.001) and disc size (β=-60.75, p=0.001). For every 1 year older in age, the LCD-PPS was deeper on average by 1.95 µm in Chinese subjects (p=0.01) but there was no association in Indians subjects (p=0.851).
The LCD was influenced by age, gender, race, Axl, RNFL, ChT, VCDR and disc size. This normative LCD database may facilitate a more accurate assessment of ONH cupping using OCT in Asian populations.
探讨中国和印度新加坡成年人健康眼的颅神经节细胞层（lamina cribrosa depth，LCD）深度的决定因素。
对 1396 名受试者（628 名中国受试者和 768 名印度受试者）的右眼视神经头（optic nerve head，ONH）进行光学相干断层扫描（optical coherence tomography，OCT，Spectralis，Heidelberg，德国）成像。LCD 定义为从 Bruch 膜开口（LCD-BMO）或视盘周围巩膜（LCD-PPS）参考平面到层状表面的距离。使用线性回归模型评估 LCD 与其决定因素之间的关系。
两种种族之间的 LCD 均有显著差异（LCD-BMO：中国受试者为 421.95（95%置信区间 365.32 至 491.79）µm，印度受试者为 430.39（367.46 至 509.81）µm，p=0.021；和 LCD-PPS：中国受试者为 353.34（300.98 至 421.45）µm，印度受试者为 376.76（313.39 至 459.78）µm，p<0.001）。在多变量回归分析中，整个队列的 LCD-PPS 与女性（β=-31.93，p<0.001）、印度受试者（β=21.39，p=0.004）（以中国人为参照）、眼轴（axial length，Axl）（β=-6.68，p=0.032）、视网膜神经纤维层厚度（retinal nerve fibre layer thickness，RNFL）（β=0.71，p=0.019）、脉络膜厚度（choroidal thickness，ChT）（β=0.41，p<0.001）、垂直杯盘比（vertical cup disc ratio，VCDR）（β=24.42，p<0.001）和视盘大小（β=-60.75，p=0.001）独立相关。每增加 1 岁，中国受试者的平均 LCD-PPS 深度增加 1.95µm（p=0.01），但印度受试者则没有关联（p=0.851）。
LCD 受年龄、性别、种族、Axl、RNFL、ChT、VCDR 和视盘大小的影响。该正常 LCD 数据库可能有助于在亚洲人群中使用 OCT 更准确地评估 ONH 杯状。
